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コンテンツは Stanford Engineering & Russ Altman and Stanford Engineering によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャスト コンテンツは、Stanford Engineering & Russ Altman and Stanford Engineering またはそのポッドキャスト プラットフォーム パートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal
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The future of exercise

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Manage episode 426099317 series 2712286
コンテンツは Stanford Engineering & Russ Altman and Stanford Engineering によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャスト コンテンツは、Stanford Engineering & Russ Altman and Stanford Engineering またはそのポッドキャスト プラットフォーム パートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal

Jonathan Long is a biochemist who studies the chemicals produced during exercise. In Long’s world, “you always start with molecules,” which offer “clean handles” to understanding complex processes. His lab has identified a chemical produced in the digestive tract during exercise that can make a person stop eating. Long now studies this “gut-brain axis” for ways to treat obesity, diabetes, and, perhaps, even age-related conditions like dementia, as he tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

Connect With Us:

Chapters:

(00:00:00) Introduction

Host Russ Altman introduces guest Jonathan Long, a professor of pathology at Stanford University

(00:02:30) Effective Weight Loss Drugs

The increase of effective weight loss drugs, and the history and development of these GLP-1 receptor agonists.

(00:04:03) Understanding Metabolism and Exercise

Outline of metabolic chemicals released during physical activity and their potential to combat obesity and diabetes.

(00:05:38) Animal Models in Exercise Studies

The use of animal models in exercise studies and the discovery of Lac-Phe.

(00:07:15) Psychological Preparation for Exercise

The psychological aspects of exercise and the involvement of endocannabinoids in exercise motivation.

(00:09:28) Lac-Phe's Role and Mechanism

The role of Lac-Phe and its production in the gut.

(00:12:21) Differences in Exercise Response

Differences in exercise response between trained athletes and untrained individuals.

(00:13:25) Diabetes and Metabolic Diseases

The relationship between diabetes, exercise, and metabolic diseases.

(00:15:29) Lac-Phe as a Potential Therapeutic

The potential of Lac-Phe as a weight loss drug, and parallels to GLP-1 drug development.

(00:16:48) Importance of How Weight is Lost

Whether the method of weight-loss matters, and the importance of preserving lean muscle mass.

(00:19:40) Exercise as Medicine

The concept of exercise as medicine, and defining physical activity at the same resolution as modern medicines.

(00:22:39) Metformin and Exercise Pathways

The unexpected connection between metformin and the Lac-Phe pathway.

(00:24:08) Prospects of an Exercise Pill

The future of an exercise pill, and the scientific challenges associated with its development.

(00:27:33) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

  continue reading

276 つのエピソード

Artwork

The future of exercise

The Future of Everything

151 subscribers

published

iconシェア
 
Manage episode 426099317 series 2712286
コンテンツは Stanford Engineering & Russ Altman and Stanford Engineering によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャスト コンテンツは、Stanford Engineering & Russ Altman and Stanford Engineering またはそのポッドキャスト プラットフォーム パートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal

Jonathan Long is a biochemist who studies the chemicals produced during exercise. In Long’s world, “you always start with molecules,” which offer “clean handles” to understanding complex processes. His lab has identified a chemical produced in the digestive tract during exercise that can make a person stop eating. Long now studies this “gut-brain axis” for ways to treat obesity, diabetes, and, perhaps, even age-related conditions like dementia, as he tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

Connect With Us:

Chapters:

(00:00:00) Introduction

Host Russ Altman introduces guest Jonathan Long, a professor of pathology at Stanford University

(00:02:30) Effective Weight Loss Drugs

The increase of effective weight loss drugs, and the history and development of these GLP-1 receptor agonists.

(00:04:03) Understanding Metabolism and Exercise

Outline of metabolic chemicals released during physical activity and their potential to combat obesity and diabetes.

(00:05:38) Animal Models in Exercise Studies

The use of animal models in exercise studies and the discovery of Lac-Phe.

(00:07:15) Psychological Preparation for Exercise

The psychological aspects of exercise and the involvement of endocannabinoids in exercise motivation.

(00:09:28) Lac-Phe's Role and Mechanism

The role of Lac-Phe and its production in the gut.

(00:12:21) Differences in Exercise Response

Differences in exercise response between trained athletes and untrained individuals.

(00:13:25) Diabetes and Metabolic Diseases

The relationship between diabetes, exercise, and metabolic diseases.

(00:15:29) Lac-Phe as a Potential Therapeutic

The potential of Lac-Phe as a weight loss drug, and parallels to GLP-1 drug development.

(00:16:48) Importance of How Weight is Lost

Whether the method of weight-loss matters, and the importance of preserving lean muscle mass.

(00:19:40) Exercise as Medicine

The concept of exercise as medicine, and defining physical activity at the same resolution as modern medicines.

(00:22:39) Metformin and Exercise Pathways

The unexpected connection between metformin and the Lac-Phe pathway.

(00:24:08) Prospects of an Exercise Pill

The future of an exercise pill, and the scientific challenges associated with its development.

(00:27:33) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

  continue reading

276 つのエピソード

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