Could You Have An ERCP-related Outbreak? Sequencing To The Rescue But You'll Have To Trash The Scope! Infection Control Matters podcast

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Fitness Medicine Australia Brett Mitchell

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コンテンツは Brett Mitchell によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャストコンテンツは、Brett Mitchell またはそのポッドキャストプラットフォームパートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal。

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Biscuits & Jam

約 2 日前2d ago

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In the South, food and music go hand in hand. They define much of what we think of as Southern culture, and they say a lot about our past, our present, and our future. Each week, Sid Evans, Editor in Chief of Southern Living, sits down with musicians, chefs, and other Southern icons to hear the stories of how they grew up, what inspires them, and why they feel connected to the region. Through honest conversations, Sid explores childhood memories, the family meals they still think about, and the intersection of food and music in their lives. Always surprising, always engaging, Biscuits & Jam is a celebration of the South—and the people who are moving it forward every day. New episodes every Tuesday.

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Could you have an ERCP-related outbreak? Sequencing to the rescue but you'll have to trash the scope!

約 1 年前 21:24

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コンテンツは Brett Mitchell によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャストコンテンツは、Brett Mitchell またはそのポッドキャストプラットフォームパートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal。

In this episode, Martin talks to Cansu Cimen, a researcher at University Hospitals Groningen in the Netherlands, about a recent paper that documents an outbreak and in particular the critical role of next-generation sequencing (NGS) in tracking and controlling the transmission of MDROs via contaminated duodenoscopes.

Focusing on an outbreak linked to ESBL-producing Citrobacter freundii and Klebsiella pneumoniae after endoscopic retrograde cholangiopancreatography (ERCP), standard culture methods failed to detect contamination. After many negative cultures using established methods, destructive dismantling of the implicated scope revealed contamination on hard-to-clean components, highlighting NGS as an effective tool for identifying pathogen transmission pathways.

Cimen C, Bathoorn E, Loeve AJ, Fliss M, Berends MS, Nagengast WB, et al. Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum beta-lactamase-producing Enterobacterales by a contaminated duodenoscope. Antimicrob Resist Infect Control 2024;13(1):31. https://doi.org/10.1186/s13756-024-01386-5.

Download the paper here

… continue reading

100 つのエピソード

#Fitness #Medicine #Australia #Brett Mitchell

Infection Control Matters

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Could you have an ERCP-related outbreak? Sequencing to the rescue but you'll have to trash the scope!

Infection Control Matters

16 subscribers

published 約 1 年前

シェア

MP3•エピソードのホーム

コンテンツは Brett Mitchell によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャストコンテンツは、Brett Mitchell またはそのポッドキャストプラットフォームパートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal。

In this episode, Martin talks to Cansu Cimen, a researcher at University Hospitals Groningen in the Netherlands, about a recent paper that documents an outbreak and in particular the critical role of next-generation sequencing (NGS) in tracking and controlling the transmission of MDROs via contaminated duodenoscopes.

Focusing on an outbreak linked to ESBL-producing Citrobacter freundii and Klebsiella pneumoniae after endoscopic retrograde cholangiopancreatography (ERCP), standard culture methods failed to detect contamination. After many negative cultures using established methods, destructive dismantling of the implicated scope revealed contamination on hard-to-clean components, highlighting NGS as an effective tool for identifying pathogen transmission pathways.

Cimen C, Bathoorn E, Loeve AJ, Fliss M, Berends MS, Nagengast WB, et al. Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum beta-lactamase-producing Enterobacterales by a contaminated duodenoscope. Antimicrob Resist Infect Control 2024;13(1):31. https://doi.org/10.1186/s13756-024-01386-5.

Download the paper here

… continue reading

100 つのエピソード

#Fitness #Medicine #Australia #Brett Mitchell

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nv-HAP surveillance too time-consuming? Semi-automated may be easier than you think 30:20

1 day前30:20

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30:20

In this episode, Phil and Martin talk to Dr Aline Wolfensberger, Senior Attending Physician, Department of Infectious Diseases and Hospital Epidemiology at University Hospital Zurich and a Senior Researcher at the Institute for Implementation Science in Health Care at the Univetsity of Zurich. We discuss a recent paper that has analysed a range of algorithms for detecting non-ventilator associated pneumonia (nvHAP) that have the potential for significantly reducing the surveillance burden. This work also demonstrated the value of an annual local hospital-wide point prevalence survey that provides data on which areas to target. Relevant reading: [1] Mueller A, Pfister M, Faes Hesse M, Zingg W, Wolfensberger A, Swissnoso G. Development and validation of selection algorithms for a non-ventilator hospital-acquired pneumonia semi-automated surveillance system. Clin Microbiol Infect 2024. https://doi.org/10.1016/j.cmi.2024.11.032 [2] Wolfensberger A, Scherrer AU, Sax H. Automated surveillance of non-ventilator-associated hospital-acquired pneumonia (nvHAP): a systematic literature review. Antimicrob Resist Infect Control 2024;13(1):30. https://doi.org/10.1186/s13756-024-01375-8 [3] Wolfensberger A, Jakob W, Faes Hesse M, Kuster SP, Meier AH, Schreiber PW, et al. Development and validation of a semi-automated surveillance system-lowering the fruit for non-ventilator-associated hospital-acquired pneumonia (nvHAP) prevention. Clin Microbiol Infect 2019;25(11):1428 e7- e13. https://doi.org/10.1016/j.cmi.2019.03.019…

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Methods of assessing effectiveness of hospital cleaning - a review and peek into the future? 25:36

約 15 日前25:36

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25:36

In this episode Martin Talks to Silvana Gastaldi who is a infection prevention and control health referent at UK-MED (a frontline humanitarian medical NGO). We discuss her revent paper in the Journal of Hospital Infection that reviews the literature on methods of assessing how effective environmental cleaning services and procedures are, including ATP, fluorescent UV marking, visual and microbiological methods and also discuss the potential for AI to assist in the healthcare environmental decontamination arena. The paper we discuss: Gastaldi S, Accorgi D, D'Ancona F. Tools and strategies for monitoring hospital environmental hygiene services. J Hosp Infect 2025. https://doi.org/10.1016/j.jhin.2025.01.011 To listen to a previous podcast in which Dr Phil Carling, developer of the UV marking systems talks about it's development and initial use please click here Podcast website and collections: www.infectioncontrolmatters.com…

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Reducing CAUTI in intermittent self-catheterisation. The trial that didn't make it.. 31:24

約 29 日前31:24

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31:24

In this episode, Phil Russo talks to Brett Mitchell and Kate Browne about a study that did not make it over the line. Following a systematic review in 2021 that examined the issue of UTIs in those who self catheterise, a study to examine whether previous work demonstrating a reduction in CAUTI in indwelling catheters through the use of Chlorhexidine for meatal cleansing would be effective was designed. The team discuss the complexities of getting what was essentially a community-based study over the line and why ultimately it did not progress, much to the sadness of the team. previous relevant work is listed below. Mitchell BG, Prael G, Curryer C, Russo PL, Fasugba O, Lowthian J, et al. The frequency of urinary tract infections and the value of antiseptics in community-dwelling people who undertake intermittent urinary catheterization: A systematic review. Am J Infect Control 2021;49(8):1058-65. https://doi.org/10.1016/j.ajic.2021.01.009 . Fasugba O, Cheng AC, Gregory V, Graves N, Koerner J, Collignon P, et al. Chlorhexidine for meatal cleaning in reducing catheter-associated urinary tract infections: a multicentre stepped-wedge randomised controlled trial. Lancet Infect Dis 2019;19(6):611-9. https://doi.org/10.1016/S1473-3099(18)30736-9 .…

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A poster walk at ACIPC 2024 17:43

6 weeks前17:43

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17:43

In this episode Brett and Phil chat about a few of the posters presented at the Australasian College for Infection Prevention and Control 2024 Conference held in Melbourne in November 2024. Poster topics include hand hygiene, surveillance, and a pilot RCT on chlorhexidine impregnated dressings. You can access poster abstracts below and a pdf of the posters here Improving Hand Hygiene Practices in the Marshall Islands Epidemiology of Hospital-acquired Bloodstream Infections at a Quaternary Hospital Service An antimicrobial dressing for prevention of infection complication related peripheral intravenous catheter: an international randomised controlled trial. Comparing Healthcare Associated Infection data to Hospital Acquired Complication Infection data collection and finding the documentation differences to improve accuracy…

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Engaging Junior Doctors in IPC 18:06

8 weeks前18:06

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18:06

In this episode recorded at the 2024 Australasian College of Infection Prevention and Control (ACIPC) Conference in Melbourne, Brett and Phil talk to Dr Sarah Browning (ID Physician at Hunter New England) and two Junior Medical Officers (JMOs) Sam and Lochlan who worked on IPC-related projects whilst on placement.…

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The 2024 End of Year Special 46:12

11 weeks前46:12

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46:12

In this episode, Brett, Phil and Martin reflect on the year. We chat about favourite podcasts, papers and conferences in our usual informal manner (well probably even more informal than normal). Papers we mention are listed below. Cimen C, Bathoorn E, Loeve AJ, Fliss M, Berends MS, Nagengast WB, et al. Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum beta-lactamase-producing Enterobacterales by a contaminated duodenoscope. Antimicrob Resist Infect Control 2024;13(1):31. https://doi.org/10.1186/s13756-024-01386-5 Torres-Teran MM, Greentree DH, Varghese MM, Cadnum JL, Pavis RL, Saade EA, et al. Identifying and Remediating Super-splasher Sinks to Reduce Dispersal of Pathogens From Sink Drains. Open Forum Infect Dis 2024;11(7):ofae293. https://doi.org/10.1093/ofid/ofae293 Bush M, Bennett CM, Hutchinson A, Bouchoucha SL. Post implementation quarantine recommendations that support preparedness: A systematic review and quarantine implementation capability framework. Infect Dis Health 2024;29(3):152-71. https://doi.org/10.1016/j.idh.2024.02.004 Dhar S, Jinadatha C, Kilgore PE, Henig O, Divine GW, Todter EN, et al. Lowering the Acquisition of Multidrug-Resistant Organisms (MDROs) With Pulsed-xenon (LAMP) Study: A Cluster-Randomized, Controlled, Double-Blinded, Interventional Crossover Trial. Clin Infect Dis 2024;79(4):1024-30. https://doi.org/10.1093/cid/ciae240 Widmer AF, Atkinson A, Kuster SP, Wolfensberger A, Klimke S, Sommerstein R, et al. Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis: A Randomized Clinical Trial. JAMA 2024;332(7):541-9. https://doi.org/10.1001/jama.2024.8531 Leistner R, Kohlmorgen B, Brodzinski A, Schwab F, Lemke E, Zakonsky G, et al. Environmental cleaning to prevent hospital-acquired infections on non-intensive care units: a pragmatic, single-centre, cluster randomized controlled, crossover trial comparing soap-based, disinfection and probiotic cleaning. EClinicalMedicine 2023;59:101958. https://doi.org/10.1016/j.eclinm.2023.101958 Denkel LA, Voss A, Caselli E, Dancer SJ, Leistner R, Gastmeier P, et al. Can probiotics trigger a paradigm shift for cleaning healthcare environments? A narrative review. Antimicrob Resist Infect Control 2024;13(1):119. https://doi.org/10.1186/s13756-024-01474-6…

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In-room air purification to prevent respiratory infection in aged care - Does it help? 32:28

13 weeks前32:28

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32:28

In this episode of ICMs we talk to the authors of a world first multi-centre double blind cross-over randomised control trial, which explored the effect of in-room air purification on acute respiratory tract infections. The rationale and pragmatics of undertaking such a trial are explored, as well as interpretation of the findings. The lead researcher, Bismi Thottiyil Sultanmuhammed Abdul, a PhD student at the University of Newcastle is joined by some of her supervisors Professors Jenny Sim and Brett Mitchell to explain this study. The paper can be accessed here: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825943?resultClick=1 Reference: Khadar, B. T. S. A., Sim, J., McDonald, V. M., McDonagh, J., Clapham, M., & Mitchell, B. G. (2024). Air Purifiers and Acute Respiratory Infections in Residential Aged Care: A Randomized Clinical Trial. JAMA Network Open , 7 (11), e2443769-e2443769.…

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Do you have enough staff in your IP Team? Calculating the staffing requirement for your program 26:10

15 weeks前26:10

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26:10

In this episode, Martin talks to Dr Rebecca Crapanzano-Sigafoos (formerly Bartles) who is Executive Director, Center for Research, Practoce and Innovation at the Association for Professionals in Infection Control and Epidemiology (APIC). We talk about about her work on staffing levels for IPC Teams, beginning with her early work looking at workload and then the recent review and paper on data obtained from the beta version of the APIC Staffing Calculator. It turns out that the vast majority of 390+ participating organisations are understaffed.. What might help however was the finding that hospitals that were better staffed had significantly lower infection rates according to accepted published data. Papers we discuss are found below: Bartles R, Dickson A, Babade O. A systematic approach to quantifying infection prevention staffing and coverage needs. Am J Infect Control 2018;46(5):487-91. https://doi.org/10.1016/j.ajic.2017.11.006 . Knighton SC, Engle J, Berkson J, Bartles R. A narrative review of how infection preventionist (IP) staffing and outcome metrics are assessed by health care organizations and factors to consider. Am J Infect Control 2024;52(1):91-106. https://doi.org/10.1016/j.ajic.2023.06.017 . Bartles R, Reese S, Gumbar A. Closing the gap on infection prevention staffing recommendations: Results from the beta version of the APIC staffing calculator. Am J Infect Control 2024. https://doi.org/10.1016/j.ajic.2024.09.004 .…

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Could you have an ERCP-related outbreak? Sequencing to the rescue but you'll have to trash the scope! 21:24

17 weeks前21:24

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21:24

In this episode, Martin talks to Cansu Cimen, a researcher at University Hospitals Groningen in the Netherlands, about a recent paper that documents an outbreak and in particular the critical role of next-generation sequencing (NGS) in tracking and controlling the transmission of MDROs via contaminated duodenoscopes. Focusing on an outbreak linked to ESBL-producing Citrobacter freundii and Klebsiella pneumoniae after endoscopic retrograde cholangiopancreatography (ERCP), standard culture methods failed to detect contamination. After many negative cultures using established methods, destructive dismantling of the implicated scope revealed contamination on hard-to-clean components, highlighting NGS as an effective tool for identifying pathogen transmission pathways. Cimen C, Bathoorn E, Loeve AJ, Fliss M, Berends MS, Nagengast WB, et al. Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum beta-lactamase-producing Enterobacterales by a contaminated duodenoscope. Antimicrob Resist Infect Control 2024;13(1):31. https://doi.org/10.1186/s13756-024-01386-5. Download the paper here…

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Reducing glove use in the ambulance service 12:13

19 weeks前12:13

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12:13

In this episode recorded live at the IPS Conference in Birmingham UK in September 2024, Martin talks to Claire Fitzsimons, Senior Infection Prevention and Control Practitioner at the Northern Ireland Ambulance Service Health and Social Care Trust. We discuss a poster that she presented at the conference that looked as ways of reducing glove use in the ambulance service through a range of improvement methodologies. A copy of the poster can be found here…

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Can sensors and AI improve cleaning and patient safety? 13:03

21 weeks前13:03

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13:03

In this episode, recorded at the 2024 Infection Prevention Society Conference in Birmingham (UK) Brett and Martin talk to Conor McGinn, Assistant Professor in the Department of Mechanical and Manufacturing Engineering at Trinity College Dublin and CEO of Akara AI, a robotics company spin-off from Trinity. We talk about a presentation that Conor gave, demonstrating how infrared sensors analysed by AI can provode feedback on techniques in the operating room and how they could improve cleaning standards in hospitals. A link to the video we discussed is here https://youtu.be/CPCFuXyQarY?si=xh1RjXAaKeKY708a and you can also see Conor's talk here https://youtu.be/3SCEkbwKhM4?si=uztJcnVIAe-vq5U8…

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Prevalence, fundamental care, UTI recorded live at the Infection Prevention Society Conference 2024 43:44

23 weeks前43:44

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43:44

In our second live session at a major conference, this episode of Infection Control Matters was recorded live at a plenary session to close day 1 of the Infection Prevention Society conference (Birmingham, UK). Our guest panelists include Dr Berit Muller-Pebody an Epidemiologist from the UK Health Security Agency, Prof Jennie Wilson from the University of West London and Dr Jacqui Prieto from The University of Southampton. The panel also fielded many questions from delegates from the floor. Topics covered include the role of mandatory surveillance, de-implementation, community based IPC, point prevalence studies, the UK PPS, fundamentals of care, urinary tract infection, pneumonia and the direction of IPC.…

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Is IPC the friend of sustainability? 12:53

24 weeks前12:53

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12:53

Dr Gemma L Saravanos (she/her) is an infectious diseases epidemiologist and a Registered Nurse leading public health research, and education of pre-registration nursing students. She is based at the Susan Wakil School of Nursing and Midwifery, University of Sydney and works across the Camperdown (Patyegarang) and Westmead (Baludarri) campuses in Sydney. In this episode, Phil chats to Gemma about an open access publication she led discussing IPC programs contribution to environmental harm, and argues the case that increased investment in IPC is crucial for sustainable health and environmental systems. Saravanos, G.L., Islam, M.S., Huang, Y. et al. Infection prevention and control programme priorities for sustainable health and environmental systems. BMC Global Public Health 2, 6 (2024). https://doi.org/10.1186/s44263-023-00031-4…

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The CLEEN study: Background and discussion with the authors 45:52

26 weeks前45:52

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45:52

Our guest host, Dr Sally Havers this week talks to some of authors from ClEaning and Enhancd DisinfectioN (CLEEN) study (including some regular voices..). The study was recently published in the Lancet Infectious Disease (link below). The CLEEN study is a world first RCT that explores the impact of cleaning and disinfection of shared medical equipment on HAIs. The study reports significant reductions in HAIs associated with increased cleaning and disinfection of shared equipment. In this chat, the background to the study is discussed, as well as some implementation and practical considerations. We also touch on the time it takes to clean, which is related to another paper from the CLEEN study recently published in the Journal of Hospital Infection. For those attending the 2024 IPS conference in Birmingham in a few weeks, Brett will be presenting the full methodology and main effectiveness results at the conference. Early cost-effectiveness data will also be presented, as well as results from a time and motion study exploring how long it takes to clean equipment. For those attending the 2024 ACIPC conference in Melbourne in November, there is a concurrent session on the main effectiveness results and a lightning session on how long it takes to clean equipment. Publications Browne, K., White, N. M., Russo, P. L., Cheng, A. C., Stewardson, A. J., Matterson, G., ... & Mitchell, B. G. (2024). Investigating the effect of enhanced cleaning and disinfection of shared medical equipment on health-care-associated infections in Australia (CLEEN): a stepped-wedge, cluster randomised, controlled trial. The Lancet Infectious Diseases . Matterson, G., Browne, K., Tehan, P., Russo, P. L., Kiernan, M., & Mitchell, B. G. (2024). Cleaning time and motion: an observational study on the time required to effectively clean shared medical equipment in hospitals. Journal of Hospital Infection .…

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Removing contact precautions - what trial do we need? 25:45

27 weeks前25:45

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25:45

In this episode, Brett and Martin discuss a recent paper from Sarah Browning and colleagues that describes how an RCT on the ending of aspects of contact precautions (gloves and aprons) for MRSA and VRE could be conducted. The paper can be found here: https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(24)00243-X/abstract Our other podcasts on contact precautions, gloves and aprons can be found here: https://infectioncontrolmatters.podbean.com/e/have-gloves-had-their-day/ https://infectioncontrolmatters.podbean.com/e/reflecting-on-a-contact-precautions-talk-at-eccmid-with-dr-gonzalo-bearman/ https://infectioncontrolmatters.podbean.com/e/25-years-of-contact-precautions-but-benefit-or-harm-and-what-is-the-evidence-with-prof-jennie-wilson/…

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