最高の Astrocytes ポッドキャスト (2024)

1
Stem Cells and the Human Brain - Medicine Informing Novel Discoveries (MIND) 1:04:09

16d ago1:04:09

1:04:09

Explore the captivating realm of brain research at UC San Diego with Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A. Furnari and Khalessi delve into groundbreaking efforts to find new treatments for neurological conditions such as brain tumors, stroke, and brain injuries, bringing hope to patients and their families. Emphasizing ethics, …

1
Bioengineering a Kidney Chip for Better Safer and Faster Drug Development 1:11:02

1M ago1:11:02

1:11:02

Catherine Yeung, Pharm.D., Ph.D., M.P.H., discusses groundbreaking advancements in kidney-on-a-chip technology, emphasizing its potential to revolutionize human health. She delves into the role of environmental toxins, such as okra toxin A, microplastics, and plasticizers, in contributing to chronic kidney disease, particularly in regions with spec…

1
Can Aging be Reversed? Stem Cells as a Key to Longevity 27:32

1M ago27:32

27:32

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair o…

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Spinal Cord Injury and Plasticity: Breathing After Injury 59:37

2M ago59:37

59:37

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI…

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Upgrading the Physiological Relevance of Human Brain Organoids 53:09

2M ago53:09

53:09

Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods…

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Alexander Disease Research Update - Episode #23: Albee Messing's presentation at the recent conference in Philadelphia 22:22

3M ago22:22

22:22

Albee Messing’s presentation at the recent Alexander disease conference in Philadelphia, August 3, 2024. Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/…

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Modeling Kidney Disease and Regeneration with Organoids Derived from Human Pluripotent Stem Cells 56:20

3M ago56:20

56:20

Benjamin Freedman, Ph.D., delves into the creation and functionality of kidney organoids. He discusses their focus on filtration over hormone functions, and answers intriguing questions about urine characterization and the necessity of organoid structures. Freedman explores the use of scaffolds for implants and ponders the philosophical implication…

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A Closer Look at...Stem Cells and Human Longevity 58:02

4M ago58:02

58:02

Can we live not only longer but healthier lives? Robert A.J. Signer and Shiri Gur-Cohen explore how stem cell research may unlock the secrets of longevity. Signer discusses the critical role stem cells play in combating aging-related diseases, such as cancer and immune system decline, by boosting their regenerative abilities. His work on hematopoie…

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Capturing Late-Onset Neurodegeneration in Patient-Derived Neurons via Direct Reprogramming - Breaking News in Stem Cells 59:16

4M ago59:16

59:16

Andrew Yoo, Ph.D., provides insight into the ongoing research on neurodegeneration and neuronal reprogramming, highlighting the complexities and challenges in modeling and understanding these processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39454]UCTV: UC San Diego による

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Alexander Disease Research Update - Episode #22: 1) anesthesia and AxD, and 2) GFAP cross-linking to itself 20:46

4M ago20:46

20:46

Albee Messing, Amy Waldman, and Natasha Snider discuss the following recent publications: [02:07] A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging Paediatric Anesthessia (in press) [10:17] Glial fibrillary acidic…

1
A Closer Look at...Stem Cells in Space 59:56

5M ago59:56

59:56

Why explore stem cells in space when we have the comfort of Earth's laboratories? Join Robert A.J. Signer, Ph.D., alongside Catriona Jamieson, M.D., Ph.D., and Alysson Muotri, Ph.D., as they delve into the untapped potential of space experiments for expediting medical breakthroughs. Patient advocate Alexandria Allen offers a poignant narrative, rev…

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Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer. 15:21

6M ago15:21

15:21

Albee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: [02:02] Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease Neurological Sciences (2024) [full text] [04:16] Discussion about Phila…

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Effects of Astrocytic Circadian Clocks Disruption on Synaptic Pruning with Anca Pasca - Breaking News in Stem Cells 55:20

6M ago55:20

55:20

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Women in Science"…

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Episode 62: Josh Mandel-Brehm - CEO, CAMP4 Therapeutics 20:10

6M ago20:10

20:10

Explore the untapped potential of RNA amplifying therapeutics with the CEO of CAMP4 Therapeutics, Josh Mandel-Brehm. We uncover the power of antisense oligonucleotides in rewriting the narrative for genetic diseases characterized by protein deficiency. Josh takes us behind the scenes of their innovative RNA Actuating Platform (RAP), a map charting …

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Episode 61: William Korinek - CEO and Co-Founder, Astrocyte Pharmaceuticals 24:20

6M ago24:20

24:20

Embark on a journey through the neurons and synapses of brain science with William Korinek, the CEO of Astrocyte Pharmaceuticals. In a conversation that fuses the molecular intricacies of neuroprotection with the humanistic pursuit of medical advancement, Bill reveals his unique path from molecular biologist to biotech innovator. Together, we unrav…

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Stem Cells and Science in Space - Medicine Informing Novel Discoveries (MIND) 53:49

6M ago53:49

53:49

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and po…

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Stem Cells and Space: Global Astrobiotechnology Hub 54:26

6M ago54:26

54:26

Marking the one-year anniversary of the Global Astrobiotechnology Hub, an esteemed panel convenes to envision the future of space exploration and stem cell research. Central to their discussion is the imperative to enhance accessibility and expedite scientific inquiry in space. They advocate for a shift towards establishing regular access to space,…

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Episode 60: Rachel Haines - VP of Clinical Development & Operations, Rinri Therapeutics 18:30

6M ago18:30

18:30

Vial による

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Episode 59: Bas van der Baan - President & CEO, Lixte Biotechnology 17:32

7M ago17:32

17:32

Join as we dive deep into the world of oncology drug development with Bas van der Baan of Lixte. Discover the inspiration behind Lixte's focus on PP2A inhibitors and how this innovative approach is poised to revolutionize cancer treatment by enhancing chemotherapy and immunotherapy responses. Bas shares insights into ongoing clinical trials, regula…

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Skin Development and Regeneration in Homeostasis and Disease with Elena Ezhkova - Breaking News in Stem Cells 1:05:49

7M ago1:05:49

1:05:49

Elena Ezhkova, Ph.D., discusses the role of Merkel cells in touch sensation and their connection to nerves. She shares research on skin cancer formation, focusing on the PRC1 complex's impact on gene expression. Ezhkova also investigates epithelial-to-mesenchymal transition (EMT), finding it contributes to cancer spread. Ezhkova offers insights for…

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Episode 58: Samarendra Mohanty - President & CSO, Nanoscope Therapeutics 16:36

7M ago16:36

16:36

Dr. Samar Mohanty, president and CSO of Nanoscope Therapeutics joins us to shed light on the revolutionary gene therapy that's giving hope to individuals with retinal degenerative diseases by pioneering a treatment that can re-sensitize the retina to detect low light levels. We open the curtains on their groundbreaking multi-characteristic opsins (…

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Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease 15:37

7M ago15:37

15:37

Albee Messing and Linghai Kong discuss the following recent publication: [01:52] 3D bioprinting of human neural tissues with functional connectivity. Cell Stem Cell 31:260-274.e7 (2024) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Cente…

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Episode 57: Rob Etherington- CEO and President at Clene Nanomedicine 20:06

8M ago20:06

20:06

Imagine unlocking the secrets to revitalizing the brain's energy centers and turning the tide on neurodegenerative diseases. In this episode, Rob introduces us to CNM-Au8, an oral nanotherapeutic with the potential to recharge failing mitochondria. Our discussion traverses the innovative path Clene has charted, from the drug's conception to the exc…

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Episode 56: Jason Bock- Founder and CEO at CTMC 22:28

8M ago22:28

22:28

Step into the future as Dr. Jason Bock, founder and CEO of CTMC discusses the company's unique approach to accelerating cell therapies from development to testing, and the power of collaboration in reshaping the future of cancer treatment. Listen in as we discuss how CTMC's partnership with MD Anderson is not just technical but deeply human in natu…

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Modeling Development with Stem Cells with Amander Clark - Breaking News in Stem Cells 1:07:59

8M ago1:07:59

1:07:59

Amander Clark, Ph.D., delves into crafting artificial ovaries for fertility and aging research. She stresses the importance of diversity in stem cell studies to ensure comprehensive findings. By assembling ovarian models from various genetic backgrounds, her team aims for inclusive representation in biomedical research, potentially offering insight…

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Episode 55: Alex Federation- Co-Founder at Talus Bio 15:27

8M ago15:27

15:27

Embark on a quest to unravel the 'undruggable' genome with Alex Federation, Co-founder of Talus Bio. Explore challenges in targeting transcription factors in cancer with Talus's innovative Marmot platform. Discover potential breakthroughs in rare diseases and pediatric cancers, and glimpse into the future of studying transcription factors within li…

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Episode 54: Ahmed Hamdy- CEO at Vincerx Pharma 16:52

9M ago16:52

16:52

Join Dr. Ahmed Hamdy, CEO of Vincerx Pharma, on a compelling journey through oncology. From co-founding Acerta Pharma to pioneering patient-centric innovations, Dr. Hamdy shares his impactful career. Explore the groundbreaking VersAptx bioconjugation platform, designed to elevate cancer therapies and uncover the delicate balance between clinical ex…

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Episode 53: Sam Clark- CEO & Founder at Terran Biosciences 18:10

9M ago18:10

18:10

Have you ever considered the untapped potential of abandoned drugs? Join Dr. Sam Clark to discuss how his personal drive to combat mental illness is leading to breakthroughs in treatments for neurological and psychiatric diseases. Witness how Terran is not only resurrecting discarded medications for new purposes, but also pioneering the next genera…

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Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease 18:24

9M ago18:24

18:24

Albee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: [00:59] Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN) Molecular Biology of the Cell (in press) [full text - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846626/] Send your questi…

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Episode 52: Mark McDonough- President & CEO of ChromaCode 16:54

9M ago16:54

16:54

Ever wondered how technology could drastically improve early detection in healthcare? Let us take you on a journey with Mark McDonough, President and CEO of ChromaCode, as we unfold the world of molecular diagnostics with a special focus on HDPCR technology. Mark, with his diverse background in the military and healthcare, brings a fresh perspectiv…

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Episode 51: Bogdan Knezevic - Co-founder & CEO at Kaleidoscope.bio 21:16

9M ago21:16

21:16

Embark on a journey through the intricate world of biotech with Bogdan Kezevic, co-founder and CEO of Kaleidoscope Bio, and uncover the revolutionary software shaping the future of scientific research. Bogdan's leap from scientist to entrepreneur has led to groundbreaking solutions for the challenges plaguing biotech. In our chat, he shares how dat…

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Episode 50: Steven Reed - Co-Founder & CEO at HDT Bio 12:19

9M ago12:19

12:19

What does it take to revolutionize the world of vaccines and touch lives across the globe? Join us on a riveting journey with Steven Reed, CEO and co-founder of HDT-Bio, as we explore the creation of the first refined tuberculosis vaccine and dive into the remarkable strides in RNA technology. This episode lifts the veil on the science that could r…

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Dissecting Human HSC Self-Renewal Mechanisms Throughout Ontogeny with Hanna Mikkola - Sanford Stem Cell Symposium 2023 33:15

10M ago33:15

33:15

Hanna Mikkola, M.D., Ph.D., shares her work in hematopoietic stem cells (HSCs) and their complex renewal process. Her research aims to unravel these cells' behavior in mice and humans, offering potential insights for future medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39258]…

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Examining the Therapeutic Potential of Stem Cell Derived Microglia with Mathew Blurton-Jones - Breaking News in Stem Cells 1:18:20

10M ago1:18:20

1:18:20

Mathew Blurton-Jones presents CRISPR-based interventions for a rare brain disorder in mice by substituting defective brain cells with healthy ones. He details experiments demonstrating the efficacy of corrected cells in mitigating brain pathologies. Blurton-Jones emphasizes the need for cautious translation to human trials, advocating gradual cell …

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Prenatal Inflammation Shapes Postnatal Immune Function by Reprogramming Fetal Hematopoiesis with Anna Beaudin - Sanford Stem Cell Symposium 2023 37:24

10M ago37:24

37:24

Anna Beaudin, Ph.D., delves into the intricacies of how prenatal inflammation impacts the immune system's blueprint, shaping its long-term function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39257]UCTV: UC San Diego による

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Episode 49: Jeffrey Bacha - Chairman, Rakovina Therapeutics 21:45

11M ago21:45

21:45

Join Jeffrey Bacha, a pioneer in the fight against cancer and the creative force behind Rakovina Therapeutics. For 25 years, Jeffrey has been reshaping the industry landscape, and today, he gives us a peek into his world of innovation. We venture into Rakovina's research and development of oncology drugs. exploring their groundbreaking technique co…

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Working Together for Better Patient Care: Alpha Clinic Directors Panel - Sanford Stem Cell Symposium 2023 56:27

11M ago56:27

56:27

CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. In this fascinating panel, clinic directors discuss advanced treatments, therapies like gene editing, and sharing knowledge and creating networks across the country for better patient care.Featuring:Ge…

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Episode 48: Jonathan Thon - Founder & CEO at STRM.BIO 21:52

11M ago21:52

21:52

Embark on a fascinating exploration of biotech entrepreneurship, guided by an expert who's been in the trenches: Jonathan Thon, CEO and founder of STRM.BIO. We'll give you an insider's view of his journey from academia to the cutting edge of biotech, unveiling his trailblazing work on platelet production and the transformative potential of extracel…

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Stem Cells and Space - Sanford Stem Cell Symposium 2023 55:24

11M ago55:24

55:24

Experts discuss the immense potential of conducting experiments and manufacturing goods in space. They explore how this could enhance our understanding of health issues, unveil new discoveries, and produce innovative technology for use on Earth. The conversation encompasses collaborations between various industries and scientists, aiming to explore…

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Episode 47: Oscar Segurado- CMO at ASC Therapeutics 22:00

11M ago22:00

22:00

Ever wondered how far we've truly come in the realm of gene and cell therapies, and where we're headed next? This captivating conversation with Oscar Segurado, the CMO of ASC Therapeutics, will satisfy your curiosity. Oscar, a veteran in the biopharmaceutical industry, shares fascinating insights on ASC Therapeutics' groundbreaking innovation in pe…

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Episodes 46: Spiro Rombotis- CEO at Cyclacel 21:28

11M ago21:28

21:28

We’re thrilled to share our enlightening exchange with Spiro Rombotis, the seasoned CEO of Cyclacel. He peels back the curtain on the breakthrough discovery of B53, a commonly mutated gene in cancer patients, and the inspiring success of FADRA, their lead drug in clinical trials. Furthermore, Spiro delves into the highs and lows faced by Cyclacel, …

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Using Stem Cells to Model and Treat Human Disease with Clive Svendsen - Sanford Stem Cell Symposium 2023 40:27

11M ago40:27

40:27

Clive Svendsen, Ph.D., leads groundbreaking experiments using stem cell transplants, uncovering unexpected findings. These trials aimed at improving ALS treatments, revealed higher success with upper motor neuron transplants compared to spinal cord methods. Svendsen's exploration of cortical transplants hints at a potential breakthrough. Moreover, …

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Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD 28:42

12M ago28:42

28:42

Albee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: [4:30] Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al. Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease. Magnetic Resonance in Medicine (2023) in press [15:11] Acquisition and Loss of…

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Organoids to Model Human Diseases with Hans Clevers - Sanford Stem Cell Symposium 2023 40:39

12M ago40:39

40:39

Hans Clevers, M.D., Ph.D., shares his research at the intersection of medicine and biology. Clevers discusses revolutionary advances in personalized medicine, where patient-specific treatments can be developed by studying small samples of patients' tissues. He explores the role of specialized cells known as "best for cells" in gastrointestinal heal…

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Regulation of Lung Progenitors in Homeostasis and Injury Repair - Carla Kim Sanford Stem Cell Symposium 2023 29:11

12M ago29:11

29:11

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]UCTV: UC San Diego による

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Clonal Hematopoiesis in Human Aging and Disease with Siddhartha Jaiswal - Sanford Stem Cell Symposium 2023 28:53

12M ago28:53

28:53

Siddhartha Jaiswal, M.D., Ph.D., discusses clonal hematopoiesis and its impact on aging and diseases. Jaiswal highlights the role of genetic variations, focusing on a specific gene, TET2, and its link to clonal expansion. He explains that certain genetic variations can slow clonal expansion, potentially offering insights into treatments or interven…

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A Life in Space with Peggy Whitson - Sanford Stem Cell Symposium 2023 39:58

12M ago39:58

39:58

Astronaut Peggy Whitson, Ph.D., and Lisa Carnell, Ph.D., discuss various aspects of space exploration, life in microgravity, and the future of space science and research. They delve into the challenges astronauts face, from taste differences in space to innovative 3D printing solutions. The conversation also highlights the importance of stem cell r…

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Telomeres in Cancer and Aging with Ronald DePinho - Sanford Stem Cell Symposium 2023 34:12

12M ago34:12

34:12

Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TER…

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Clonal Expansion of Blood Stem Cells in Aging and Leukemia with Leonard Zon - Sanford Stem Cell Symposium 2023 48:38

1y ago48:38

48:38

Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular …

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Episode 45: Frank Borriello- Founder and CEO at Alloplex Biotherapeutics 17:56

1y ago17:56

17:56

Ever wondered about the people who are leading the fight against cancer, developing groundbreaking treatments, and changing lives? Meet Frank Boriello, the mind behind SUPLEXA cell therapy, and the CEO and founder of Alloplex Biotherapeutics. In our conversation, Frank shares the personal backstory that sparked his quest to revolutionize cancer tre…

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ポッドキャスト Astrocytes

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