#50 - Acute catabolic (yes, catabolic...) response of bone to exercise with Dr Wendy Kohrt

Inside Exercise

Dr Glenn McConell chats with Professor Wendy Kohrt from the University of Colorado Anschutz Medical Campus. She has an extremely strong track record of research on how exercise affects bone. She has changed her thinking of late after finding that acute exercise actually has a catabolic effect on bone even though overall, it can have beneficial effects. This is dependent on the actual exercise/sport undertaken and the duration. A very interesting chat.
0:00. Introduction/overview of Wendy’s exercise and research background
5:26. How Wendy got interested in bone/John Holloszy
8:48. Exercise, bone loss and NSAIDs
13:08. Cyclists have low bone density and possible mechanisms
18.44. Sweat calcium loss results in low bone density in cyclists?
23:54. Serum calcium decreases within 15 min of cycling exercise
25:58. Parathyroid hormone increases during cycling exercise
30:20. Calcium clamp during cycling exercise to prevent reduction in serum calcium
33:40. Bone breakdown during cycling exercise that continues for a period after exercise
36:15. What about walking/running?
38:50. Calcium clamp to prevent reductions in serum calcium prevents more of bone breakdown
40:15. When serum calcium decreases, where is the calcium going? Muscle mitochondria?
43:38. Calcium tracer experiments to determine turnover etc during exercise
47:00. Calcium supplementation before exercise?
49:20. Serum calcium levels during running exercise
51:37. So is exercise bad for bone? Paradoxical effects of Parathyroid hormone on bone
54:15. Pharmacological transient increases in parathyroid hormone stimulates bone formation
56:52. Is exercise good for bone health?
59:30. Wendy's current studies
1:03:06. Other effects of bone markers on metabolism etc?
1:05:10. Peak bone mass in late teens/early 20's very important / aging and bone
1:08:28. Calcium and Vit D supplementation and bone
1:11:24. Bone mass in people who have undertaken different types of sports
1:15:26. Should people supplement with calcium before exercise?
1:17:04. Wendy's involvement with the MoTrPAC NIH common fund initiative
1:25:37. Takeaway messages
1:27:30. Serum calcium changes during exercise and the heart?
1:29:04. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
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Not medical advice