Dyes, Drugs, And Psychosis Distillations | Science History Institute podcast

Artwork

Science History Science History Institute Chemistry Society Technology LifeSciences

Player FM - Internet Radio Done Right

two 年前前追加した

コンテンツは Science History Institute によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャストコンテンツは、Science History Institute またはそのポッドキャストプラットフォームパートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal。

<

<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/series-2996722">The So What from BCG</a></span>

<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/series-2996722">The So What from BCG</a></span> podcast artwork

<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/series-2996722">The So What from BCG</a></span> podcast artwork

1
The So What from BCG

約 6 日前6d ago

月ごとの+

This podcast from Boston Consulting Group looks around the corner of today’s big business and social issues. The goal–the so what–is to make sense of today and prepare busy leaders and executives for the day after tomorrow. Award-winning British journalist Georgie Frost interviews the leading thinkers and doers at BCG on the trends, developments, and ideas that will shape and disrupt the future. This is not your typical business strategy podcast.

Distillations | Science History Institute « »
Dyes, Drugs, and Psychosis

約 1 年前 35:23

シェア

MP3•エピソードのホーム

コンテンツは Science History Institute によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャストコンテンツは、Science History Institute またはそのポッドキャストプラットフォームパートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal。

In 1856, Henry Perkin's attempt to synthesize quinine led to something very different: a vibrant purple dye. Perkin’s mauve revolutionized the fashion industry when Queen Victoria wore a dress of the color to her daughter's wedding. And in an ironic twist, synthetic fabric dyes ultimately led to synthetic drugs, including the first antipsychotic. This drug, known by its trade name Thorazine, was a gamechanger. “Nobody thought there could be a drug that would treat schizophrenia effectively,” says sociologist Andrew Scull, “and then suddenly there was.” In this episode we explore the enduring relationship between dyes and drugs, and the role that mistakes and serendipity still play in drug development.

Credits

Host: Alexis Pedrick Executive Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.

… continue reading

350 つのエピソード

#Science #History #Science History Institute #Chemistry #Society #Technology #LifeSciences

Artwork

Dyes, Drugs, and Psychosis

Distillations | Science History Institute

published 約 1 年前

シェア

MP3•エピソードのホーム

コンテンツは Science History Institute によって提供されます。エピソード、グラフィック、ポッドキャストの説明を含むすべてのポッドキャストコンテンツは、Science History Institute またはそのポッドキャストプラットフォームパートナーによって直接アップロードされ、提供されます。誰かがあなたの著作物をあなたの許可なく使用していると思われる場合は、ここで概説されているプロセスに従うことができますhttps://ja.player.fm/legal。

In 1856, Henry Perkin's attempt to synthesize quinine led to something very different: a vibrant purple dye. Perkin’s mauve revolutionized the fashion industry when Queen Victoria wore a dress of the color to her daughter's wedding. And in an ironic twist, synthetic fabric dyes ultimately led to synthetic drugs, including the first antipsychotic. This drug, known by its trade name Thorazine, was a gamechanger. “Nobody thought there could be a drug that would treat schizophrenia effectively,” says sociologist Andrew Scull, “and then suddenly there was.” In this episode we explore the enduring relationship between dyes and drugs, and the role that mistakes and serendipity still play in drug development.

Credits

Host: Alexis Pedrick Executive Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.

… continue reading

350 つのエピソード

#Science #History #Science History Institute #Chemistry #Society #Technology #LifeSciences

すべてのエピソード

×

Artwork

1
Science, Interrupted: Part 2 44:24

約 14 日前44:24

「あとで再生する」

「あとで再生する」

気に入った

44:24

Genetic engineering breakthroughs in the late 1960s and early 1970s came with a lot of promise—and peril too. Fears about what could happen with recombinant DNA experiments put scientists in the middle of a moral dilemma. Did they have a responsibility to consider how others might use their work? Or was their place simply to be on the lab bench? In this two-part episode, we’ll share the story about the first time scientists stopped and considered the ramifications of their work, with a self-imposed moratorium. And we’ll explore all the controversy that led to the historic pivotal meeting at the Asilomar Conference Grounds in 1975 to determine the future of genetic engineering. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer Music by Blue Dot Sessions Resource List A Deep Conversation with Jon Beckwith: A History of Scientific and Social Activism . University of California Television. YouTube. Berg, Paul. "Paul Berg Letter." Wellcome Collection . Chemical Heritage Foundation: The Emergence of Biotechnology . Science History Institute . Cobb, Matthew. As Gods: A Moral History of the Genetic Age. New York: Basic Books, 2021. Cohen, Stanley N. Science, Biotechnology, and Recombinant DNA: A Personal History . UC Berkeley. DNA Learning Center. "Asilomar Meeting." Genetic Dreams, Genetic Nightmares . BBC. Fredrickson, Donald S. Asilomar and Recombinant DNA: The End of the Beginning . DNA: The Secret of Life . IMDb. Jurassic Park . IMDb. Late 1960s-Early 1970s Anti-War Marches . YouTube. "Letter from Maxine Singer and Dieter Söll to Philip Handler." Lear, John. Recombinant DNA: The Untold Story . Goodreads . Mukherjee, Siddhartha. The Gene: An Intimate History . Simon & Schuster . McElheny, Victor. Attempting the Impossible at Asilomar . McElheny, Victor. Gene Transplants Seen Helping Farmers and Doctors . The New York Times , May 20, 1974. Nova: The Gene Engineers . Dailymotion. Protein Synthesis: An Epic on the Cellular Level . YouTube. Rejection of Science Worries American Scientists . The New York Times , April 5, 1970. Rogers, Michael. The Pandora’s Box Congress . Rolling Stone . The Gene: PBS. PBS Learning Media. "The MacNeil/Lehrer Report: Genetic Engineering." American Archive of Public Broadcasting.…

Artwork

1
Science, Interrupted: Part 1 41:55

約 15 日前41:55

「あとで再生する」

「あとで再生する」

気に入った

41:55

Genetic engineering breakthroughs in the late 1960s and early 1970s came with a lot of promise—and peril too. Fears about what could happen with recombinant DNA experiments put scientists in the middle of a moral dilemma. Did they have a responsibility to consider how others might use their work? Or was their place simply to be on the lab bench? In this two-part episode, we’ll share the story about the first time scientists stopped and considered the ramifications of their work, with a self-imposed moratorium. And we’ll explore all the controversy that led to the historic pivotal meeting at the Asilomar Conference Grounds in 1975 to determine the future of genetic engineering. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer Music by Blue Dot Sessions Resource List A Deep Conversation with Jon Beckwith: A History of Scientific and Social Activism . University of California Television. YouTube. Berg, Paul. "Paul Berg Letter." Wellcome Collection . Chemical Heritage Foundation: The Emergence of Biotechnology . Science History Institute . Cobb, Matthew. As Gods: A Moral History of the Genetic Age. New York: Basic Books, 2021. Cohen, Stanley N. Science, Biotechnology, and Recombinant DNA: A Personal History . UC Berkeley. DNA Learning Center. "Asilomar Meeting." Genetic Dreams, Genetic Nightmares . BBC. Fredrickson, Donald S. Asilomar and Recombinant DNA: The End of the Beginning . DNA: The Secret of Life . IMDb. Jurassic Park . IMDb. Late 1960s-Early 1970s Anti-War Marches . YouTube. "Letter from Maxine Singer and Dieter Söll to Philip Handler." Lear, John. Recombinant DNA: The Untold Story . Goodreads . Mukherjee, Siddhartha. The Gene: An Intimate History . Simon & Schuster . McElheny, Victor. Attempting the Impossible at Asilomar . McElheny, Victor. Gene Transplants Seen Helping Farmers and Doctors . The New York Times , May 20, 1974. Nova: The Gene Engineers . Dailymotion. Protein Synthesis: An Epic on the Cellular Level . YouTube. Rejection of Science Worries American Scientists . The New York Times , April 5, 1970. Rogers, Michael. The Pandora’s Box Congress . Rolling Stone . The Gene: PBS. PBS Learning Media. "The MacNeil/Lehrer Report: Genetic Engineering." American Archive of Public Broadcasting.…

Artwork

1
ALS Patients Take on the FDA 47:41

31 weeks前47:41

「あとで再生する」

「あとで再生する」

気に入った

47:41

ALS is a fatal neurological disease that kills motor neurons. Even though it was first described more than 150 years ago, there is no cure, and the few drugs available only dampen the symptoms or slow the progression by a few months. In recent years new drugs have emerged. However, there is one problem: the life expectancy is just two to five years after diagnosis. This timeline is incompatible with the FDA drug approval process, which takes years and even decades. This has created a tense situation for desperate patients who are demanding the FDA approve unproven drugs. What’s the harm in giving desperate patients an imperfect drug? Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
The Fraud that Transformed Psychiatry 58:09

32 weeks前58:09

「あとで再生する」

「あとで再生する」

気に入った

58:09

In 1973 a bombshell study appeared in the premier scientific journal Science . It was called “On Being Sane in Insane Places.” Its author, a Stanford psychology professor named David Rosenhan, claimed that by faking their way into psychiatric hospitals, he and eight other pseudo-patients had proven that psychiatrists were unable to diagnose mental illness accurately. Psychiatrists panicked, and, as a result, re-wrote what’s known as “psychiatry’s bible”—the Diagnostic and Statistical Manual of Mental Disorders, or DSM. The study and the subsequent overhaul of the DSM changed the field forever. So it was a surprise when, decades later, a journalist reopened Rosenhan’s files and discovered that the study was full of inconsistencies and even blatant fraud. So should we throw out everything it revealed? Or can something based on a lie still contain any truths? Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
Cancer Virus Hunters: An Interview with Gregory J. Morgan 35:35

33 weeks前35:35

「あとで再生する」

「あとで再生する」

気に入った

35:35

For more than 100 years, biologists who suggested that some cancers may be caused by viruses were the pariahs of genetics. However, they persevered and incrementally built their knowledge, leading to the discovery of retroviruses, the development of a test to diagnose HIV, and the creation of the HPV vaccine. Join us as we interview Gregory J. Morgan about his book Cancer Virus Hunters: A History of Tumor Virology . Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
The Ames Test 43:27

34 weeks前43:27

「あとで再生する」

「あとで再生する」

気に入った

43:27

In 1973 biochemist Bruce Ames created a simple test that showed if chemicals had the potential to cause cancer. The Ames test made him a hero of the emerging environmental movement. But then he completely changed course and said concerns about chemicals were overblown. So what happened? Did Ames change? Or did our understanding of what causes cancer change? Featured Oral History Bruce N. Ames, "Bruce N. Ames: The Marriage of Biochemistry and Genetics at Caltech, the NIH, UC Berkeley, and CHORI, 1954–2018" conducted by Paul Burnett in 2019 and 2020, Oral History Center, The Bancroft Library, University of California, Berkeley, 2021. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
Is Ozempic Different? 43:48

35 weeks前43:48

「あとで再生する」

「あとで再生する」

気に入った

43:48

Ozempic and others in this family of drugs are nothing short of miraculous. Meant to treat Type 2 Diabetes, the drug exploded in popularity after researchers found that patients were reporting losing 15-21% of their body weight in clinical trials. There were some side effects, but none so severe that it raised concerns. Doctors began prescribing it to people who weren't diabetic but could benefit from weight loss, and now, our only problem seems to be getting enough of it for all the people who need it. It all seems magical, but is it too good to be true? Join us as we dive into the history of weight loss drugs, drug manufacturing regulations, and the role we think medicine should play in our lives. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
Traffication: An Interview with Paul Donald 45:18

36 weeks前45:18

「あとで再生する」

「あとで再生する」

気に入った

45:18

The impact of cars on wildlife extends beyond roadkill, affecting species that never venture near roads. Car noise disrupts bird communication and behavior, and tire and brake dust from pollutes waterways with microplastics. In this wide-ranging interview, we talk to the author of Traffication: How Cars Destroy Nature and What We Can Do About It , Paul Donald about how he coined the term "traffication," the history of road ecology, and what we can do about the problem. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
Dyes, Drugs, and Psychosis 35:23

37 weeks前35:23

「あとで再生する」

「あとで再生する」

気に入った

35:23

In 1856, Henry Perkin's attempt to synthesize quinine led to something very different: a vibrant purple dye. Perkin’s mauve revolutionized the fashion industry when Queen Victoria wore a dress of the color to her daughter's wedding. And in an ironic twist, synthetic fabric dyes ultimately led to synthetic drugs, including the first antipsychotic. This drug, known by its trade name Thorazine, was a gamechanger. “Nobody thought there could be a drug that would treat schizophrenia effectively,” says sociologist Andrew Scull, “and then suddenly there was.” In this episode we explore the enduring relationship between dyes and drugs, and the role that mistakes and serendipity still play in drug development. Credits Host: Alexis Pedrick Executive Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions.…

Artwork

1
Pink: An Interview with Dominique Grisard 23:10

38 weeks前23:10

「あとで再生する」

「あとで再生する」

気に入った

23:10

The color pink has long been in vogue, and when Barbie hit theaters in 2023, its appeal only increased. But its popularity dates back much further than the Mattel doll. In this bonus episode, Dr. Dominique Grisard, a gender studies professor at the University of Basel, discusses the hue and its ties to femininity, class, and Whiteness, as well as how pink has been used to subdue men in detention centers. This episode was inspired by our museum exhibition, BOLD: Color from Test Tube to Textile , on view through August 3, 2024. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
Can Color Heal Us? 39:28

38 weeks前39:28

「あとで再生する」

「あとで再生する」

気に入った

39:28

For centuries people have been drawn to the potential healing powers of colored light. From a civil war general to a Thomas Edison wannabe, people have touted it as a medical miracle. Despite claims to the contrary, though, colored light won’t regrow limbs or heal burns. And yet, we are still drawn to the idea that somehow it can fix us. Today there are actual medical studies investigating the health benefits of colored light. So is there any validity to the claims of the past? Can color really heal us? This episode was inspired by our museum exhibition, BOLD: Color from Test Tube to Textile , on view through August 3, 2024. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
The Word for Blue 39:13

39 weeks前39:13

「あとで再生する」

「あとで再生する」

気に入った

39:13

In his epic poem, The Odyssey , Homer mentions the colors black, white, red, and yellow. But despite numerous mentions of the brilliant Greek sea and sky, the word blue never makes an appearance. This omission set off a debate between perception and language that would repeat itself over and over again throughout history: was there something wrong with the ancient Greek’s eyes? If they didn’t name blue, did that mean they couldn’t see it? We treat color like it's a clear measure of whether or not our brains are working the same. We expect an answer we can all agree on. Only it turns out some colors elude us. So when it comes to blue, are we truly seeing things differently or just seeing the same thing and describing it differently? Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
New Season Trailer! Coming June 4th 2:52

40 weeks前2:52

「あとで再生する」

「あとで再生する」

気に入った

2:52

Check out our new season, dropping weekly on Tuesdays, starting June 4th.

Artwork

1
Exploring 'Health Equity Tourism' 47:07

1 year前47:07

「あとで再生する」

「あとで再生する」

気に入った

47:07

In the wake of the murder of George Floyd and the COVID-19 pandemic, there has been a new public interest in health inequities research. With this new focus, there also has come new funding with many researchers and institutions clamoring to receive lucrative funding and recognition in the field, but there are no official guidelines to distinguish a health equity expert. In this episode we sit down with Dr. Elle Lett who coined the term "health equity tourism" to describe when privileged and previously unengaged scholars enter the health equity field without developing the necessary expertise. Credits Hosts: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producers: Padmini Raghunath & Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions…

Artwork

1
The Mothers of Gynecology 56:57

2 years前56:57

「あとで再生する」

「あとで再生する」

気に入った

56:57

Of all wealthy countries, the United States is the most dangerous place to have a baby. Our maternal mortality rate is abysmal, and over the past five years it’s only gotten worse. And there are huge racial disparities: Black women are three times more likely to die than white women. Despite some claims to the contrary, the problem isn’t race, it’s racism. In this episode we trace the origins of this harrowing statistic back to the dawn of American gynecology—a field that was built on the bodies of enslaved women. And we’ll meet eight women who have dedicated their lives to understanding and solving this complex problem. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer . Additional music by Blue Dot Sessions .…

プレーヤーFMへようこそ！

Player FMは今からすぐに楽しめるために高品質のポッドキャストをウェブでスキャンしています。これは最高のポッドキャストアプリで、Android、iPhone、そしてWebで動作します。全ての端末で購読を同期するためにサインアップしてください。

500+以上のトピックを聴こう

クイックリファレンスガイド

トップポッドキャスト

鈴木淑子の地球は競馬でまわってる

文化放送競馬中継～今週のメインレース

ボードゲームおっぱい

聴く日経ヘッドライン

サンドウィッチマンの東北魂

トータルテンボスのぬきさしならナイト！

流行りモノ通信簿

RADIO365-TOKYO BAYSIDE RADIO STATION

町田徹のふかぼり！

トレンドウォッチ

伊藤洋一のRound Up World Now！

The other side journal

KIQTAS（キクタス）

ヴォイニッチの科学書

武田邦彦のヒバリクラブ

IchibanTalk 海外で頑張る日本人トーク

探検しながらこの番組を聞いてください