The Lancet Gastroenterology & Hepatology is a monthly journal that considers original research, reviews, and personal views in gastroenterology and hepatology from around the world. In the monthly podcasts, editors of the journal discuss highlights of the current issue.
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Hugh Thomas, Deputy Editor at The Lancet Gastroenterology & Hepatology, in conversation with the journal’s authors, explores their latest research and its impact on people’s health, healthcare, and health policy. A monthly audio companion to the journal, this podcast covers a broad range of topics, from predicting clinical outcomes in NAFLD to immunosuppressant withdrawal in patients with Crohn’s disease, the primary antibiotic resistance of Helicobacter pylori to surgical versus non-surgica ...
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Arndt Vogel (Toronto General Hospital) discusses the NALIRICC trial of nanoliposomal irinotecan added to fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies.The Lancet による
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Arndt Vogel on the NALIRICC trial of nanoliposomal irinotecan in pretreated advanced biliary tract cancer
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Arndt Vogel (Toronto General Hospital) discusses the NALIRICC trial of nanoliposomal irinotecan added to fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00119-5?dgc…
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Nancy Baxter (University of Melbourne) discusses a population-based study on the duration of risk reduction in colorectal cancer incidence and mortality after a complete colonoscopy.The Lancet による
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Nancy Baxter on the duration of colorectal cancer risk reduction with a complete colonoscopy
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Nancy Baxter (University of Melbourne) discusses a population-based study on the duration of risk reduction in colorectal cancer incidence and mortality after a complete colonoscopy. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00084-0?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversatio…
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In conversation with... Sanna Nybacka and Magnus Simrén
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Sanna Nybacka and Magnus Simrén (University of Gothenburg) discuss the CARIBS randomised controlled trial of a low FODMAP diet versus a low-carbohydrate diet versus pharmacological treatment in IBS.The Lancet による
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Sanna Nybacka and Magnus Simrén on a trial of low FODMAP diets versus low carbohydrate diets in IBS
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Sanna Nybacka and Magnus Simrén (University of Gothenburg) discuss the CARIBS randomised controlled trial of a low FODMAP diet versus a low-carbohydrate diet versus pharmacological treatment in IBS. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00045-1/fulltext?dgcid=buzzsprout_tlv_podcast_generic_langas …
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Nuru Noor (University of Cambridge) discusses the PROFILE trial of biomarker-stratified treatment strategies in people with newly diagnosed Crohn's disease.The Lancet による
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Nuru Noor on the PROFILE trial of biomarker-stratified treatment in newly diagnosed Crohn's disease
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Nuru Noor (University of Cambridge) discusses the PROFILE trial of biomarker-stratified treatment strategies in people with newly diagnosed Crohn's disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00034-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Foll…
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Yusuke Shimakawa (Institut Pasteur) discusses the development and evaluation of a simple score for hepatitis B treatment eligibility in Africa.The Lancet による
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Yusuke Shimakawa on a simple score for hepatitis B treatment eligibility in Africa
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Yusuke Shimakawa (Institut Pasteur) discusses the development and evaluation of a simple score for hepatitis B treatment eligibility in Africa. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00449-1?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... http…
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Mads Israelsen on validating the new steatotic liver disease nomenclature in people with excessive alcohol intake
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Mads Israelsen (Odense University Hospital) discusses a study to validate the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00443-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this convers…
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Mads Israelsen (Odense University Hospital) discusses a study to validate the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake.The Lancet による
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Louise Dye on the role of expectancy and gluten in non-coeliac gluten sensitivity
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Louise Dye (University of Leeds) discusses a trial exploring the role of expectancy and gluten ingestion on symptoms in people with non-coeliac gluten sensitivity. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00317-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on socia…
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Louise Dye (University of Leeds) discusses a trial exploring the role of expectancy and gluten ingestion on symptoms in people with non-coeliac gluten sensitivity.The Lancet による
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Tzu-Chan Hong (National Taiwan University Cancer Centre) discusses a systematic review and meta-analysis on primary antibiotic resistance of Helicobacter pylori between 1990 and 2022 in the Asia-Pacific region.The Lancet による
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Tzu-Chan Hong on the primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region
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Tzu-Chan Hong (National Taiwan University Cancer Centre) discusses a systematic review and meta-analysis on primary antibiotic resistance of Helicobacter pylori between 1990 and 2022 in the Asia-Pacific region. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00281-9/fulltext?dgcid=buzzsprout_icw_podcast_gen…
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Sarah Moen on metachronous colorectal cancer risk according to Lynch syndrome pathogenic variant after colectomy
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Sarah Moen (Erasmus University Medical Center) discusses a retrospective cohort study examining the risk of metachronous colorectal cancer after partial or extensive colectomy in carriers of different pathogenic Lynch syndrome variants. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00228-5/fulltext?dgcid=…
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Sarah Moen (Erasmus University Medical Center) discusses a retrospective cohort study examining the risk of metachronous colorectal cancer after partial or extensive colectomy in carriers of different pathogenic Lynch syndrome variants.The Lancet による
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Anna Emilie Kann (Zealand University Hospital, Denmark) discusses a population-based study done in Denmark exploring the causes of mortality in patients with alcohol-related liver disease.The Lancet による
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Anna Emilie Kann on the causes of mortality in patients with alcohol-related liver disease
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Anna Emilie Kann (Zealand University Hospital, Denmark) discusses a population-based study done in Denmark exploring the causes of mortality in patients with alcohol-related liver disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00192-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue t…
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Robert Krouse on surgical versus non-surgical management of malignant bowel obstruction
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Robert Krouse (University of Pennsylvania) discusses the pragmatic S1316 trial of surgical versus non-surgical management for patients with malignant small bowel obstruction. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00191-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversati…
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Robert Krouse (University of Pennsylvania) discusses the pragmatic S1316 trial of surgical versus non-surgical management for patients with malignant small bowel obstruction.The Lancet による
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Marc Rothenberg on a trial of benralizumab in eosinophilic gastritis
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Marc Rothenberg (University of Cincinnati College of Medicine) discusses a new trial assessing the efficacy and safety of benralizumab in patients with eosinophilic gastritis, and how the surprising findings might change our understanding of eosinophilic gastrointestinal diseases. Read the full article: https://www.thelancet.com/journals/langas/art…
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Marc Rothenberg (University of Cincinnati College of Medicine) discusses a new trial assessing the efficacy and safety of benralizumab in patients with eosinophilic gastritis, and how the surprising findings might change our understanding of eosinophilic gastrointestinal diseases.The Lancet による
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Michael Pavlides (University of Oxford) discusses work by the LITMUS Consortium on the prognostic performance of non-invasive tests in patients with non-alcoholic fatty liver disease.The Lancet による
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Michael Pavlides on non-invasive tests for predicting clinical outcomes in non-alcoholic fatty liver disease
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Michael Pavlides (University of Oxford) discusses work by the LITMUS Consortium on the prognostic performance of non-invasive tests in patients with non-alcoholic fatty liver disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00017-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this c…
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Jasmohan Bajaj on global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis
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Jasmohan Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System, Richmond, VA, USA), on behalf of the CLEARED Consortium, discusses a prospective observational cohort study examining global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis. Read the full article: https://www.…
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Jasmohan Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System, Richmond, VA, USA), on behalf of the CLEARED Consortium, discusses a prospective observational cohort study examining global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis.…
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Adelina Artenie (University of Bristol, UK) discusses a systematic review and meta-analysis exploring the incidence of HIV and HCV among people who inject drugs, and associations with age and sex or gender.The Lancet による
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Adelina Artenie on the incidence of HIV and HCV in people who inject drugs
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Adelina Artenie (University of Bristol, UK) discusses a systematic review and meta-analysis exploring the incidence of HIV and HCV among people who inject drugs, and associations with age and sex or gender. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00018-3/fulltext?dgcid=buzzsprout_icw_podcast_langas_…
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Johan Burisch (Copenhagen University Hospital, Denmark) discusses the findings and recommendations of The Lancet Gastroenterology & Hepatology Commission on the cost of inflammatory bowel disease in high-income settings.The Lancet による
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Johan Burisch on the costs of inflammatory bowel disease in high-income settings
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Johan Burisch (Copenhagen University Hospital, Denmark) discusses the findings and recommendations of The Lancet Gastroenterology & Hepatology Commission on the cost of inflammatory bowel disease in high-income settings. Read the Commission here: The cost of inflammatory bowel disease in high-income settings Continue this conversation on social! Fo…
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Edouard Louis (University Hospital CHU of Liège) discusses the SPARE randomised controlled trial of infliximab or concomitant immunosuppressant withdrawal in patients with Crohn’s disease.The Lancet による
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Edouard Louis on the SPARE trial of infliximab or immunosuppressant withdrawal in Crohn’s disease
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Edouard Louis (University Hospital CHU of Liège) discusses the SPARE randomised controlled trial of infliximab or concomitant immunosuppressant withdrawal in patients with Crohn’s disease. Read the full article: Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn's disease on combination therapy (SPARE) Continue…
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Paula Ghaneh (University of Liverpool) discusses the ESPAC5 randomised controlled trial of short-course neoadjuvant therapy compared with immediate surgery for patients with borderline resectable pancreatic ductal adenocarcinoma.The Lancet による
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Paula Ghaneh on the ESPAC5 trial of neoadjuvant therapy in borderline resectable pancreatic cancer
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Paula Ghaneh (University of Liverpool) discusses the ESPAC5 randomised controlled trial of short-course neoadjuvant therapy compared with immediate surgery for patients with borderline resectable pancreatic ductal adenocarcinoma. Read the full article: Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINO…
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Dan Turner (Shaare Zedek Medical Center) discusses the VEDOKIDS study on the safety, effectiveness, and dosing of vedolizumab in children with IBD.The Lancet による
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Dan Turner on vedolizumab in children with IBD
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Dan Turner (Shaare Zedek Medical Center) discusses the VEDOKIDS study on the safety, effectiveness, and dosing of vedolizumab in children with IBD. Read the full article: Outcomes, dosing, and predictors of vedolizumab treatment in children with inflammatory bowel disease (VEDOKIDS) Continue this conversation on social! Follow us today at... https:…
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Simon Baunwall (Aarhus University Hospital) discusses the EarlyFMT trial, a randomized placebo-controlled trial of faecal microbiota transplantation for first or second Clostridioides difficile infection.The Lancet による
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Simon Baunwall on faecal microbiota transplantation for first or second Clostridioides difficile infection
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Simon Baunwall (Aarhus University Hospital) discusses the EarlyFMT trial, a randomized placebo-controlled trial of faecal microbiota transplantation for first or second Clostridioides difficile infection. Read the full article: Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT) Continue this conversa…
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James Alexander (Imperial College London) discusses the latest findings from the VIP case-control study, which is investigating COVID-19 vaccine immune responses in immunosuppressed patients with inflammatory bowel disease.The Lancet による
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James Alexander on immune responses to COVID-19 vaccination in patients with IBD
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James Alexander (Imperial College London) discusses the latest findings from the VIP case-control study, which is investigating COVID-19 vaccine immune responses in immunosuppressed patients with inflammatory bowel disease. Read the full article: COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory b…
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Filip Knop on liraglutide for bile acid diarrhoea
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Filip Knop (University of Copenhagen) discusses a trial of liraglutide versus colesevelam for the treatment of bile acid diarrhoea.The Lancet による
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Filip Knop on liraglutide for bile acid diarrhoea
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Filip Knop (University of Copenhagen) discusses a trial of liraglutide versus colesevelam for the treatment of bile acid diarrhoea. Read the full article: Safety and efficacy of liraglutide versus colesevelam for the treatment of bile acid diarrhoea: a randomised, double-blind, active-comparator, non-inferiority clinical trial Continue this convers…
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Edward Kim (Icahn School of Medicine at Mount Sinai) discusses the single-arm RASER study of radiation segmentectomy for patients with unresectable very early to early stage hepatocellular carcinoma.The Lancet による
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Edward Kim on radiation segmentectomy for unresectable very early to early stage hepatocellular carcinoma
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Edward Kim (Icahn School of Medicine at Mount Sinai) discusses the single-arm RASER study of radiation segmentectomy for patients with unresectable very early to early stage hepatocellular carcinoma. Read the full article: Radiation segmentectomy for curative intent of unresectable very early to early stage hepatocellular carcinoma (RASER): a singl…
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Joep Ijspeert on serrated polyp detection and risk of interval post-colonoscopy colorectal cancer
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Joep Ijspeert (Amsterdam University Medical Center) discusses a population-based study exploring the detection of proximal serrated polyps and interval post-colonoscopy colorectal cancer risk. Read the full article: Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: a population-based study Continue this conversation …
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Joep Ijspeert (Amsterdam University Medical Center) discusses a population-based study exploring the detection of proximal serrated polyps and interval post-colonoscopy colorectal cancer risk.The Lancet による
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Elise Meima-van Praag (Amsterdam University Medical Centre) discusses the PISA-II trial, investigating short-term anti-TNF therapy with surgical closure versus anti-TNF therapy for perianal fistulas in Crohn's disease.The Lancet による
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Elise Meima-van Praag on surgical closure for Crohn’s disease perianal fistulas
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Elise Meima-van Praag (Amsterdam University Medical Centre) discusses the PISA-II trial, investigating short-term anti-TNF therapy with surgical closure versus anti-TNF therapy for perianal fistulas in Crohn's disease. Read the full article: Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy in the treatment of perianal fistu…
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