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Post comments, criticisms and questions you may have in Biochemistry to help this blog develop. Use this as often as you need. The more we communicate...the more you learn. This material assumes an advanced understanding of biology and chemistry as all of these videos are created after the actual lecture presentations on the topics. Send me your comments!!
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Chem 102 General Organic and Biochemistry 2 Fall 2011
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Chem 102 General Organic and Biochemistry 2 Fall 2011
James Paulson Fall 2011
This is a feed of pages for Chem 102 General Organic and Biochemistry 2 Fall 2011
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Behind the Biochemistry is YOUR go-to podcast to engage with your inner scientific curiousty! On this podcast we will bust out the beakers to dive into the depths of topics such as cellular pathways that are essential to our daily lives & what happens when these are influenced via a variety of factors. We will include special guests and go and visit researchers and scientific entrepreneurs. It's time to have some fun, bust out the beakers, and find out what it BEHIND THE BIOCHEMISTRY!
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BioMedical PortraitVI.C.14.Liver NK cell chemokine recruitment and the significant role of obesity in possible immunotoxicity in HCC ontogeny.DJGPhD.30.11.23
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References Journal of Hepatology 2012 56, 704-713DOI Eur J Immunol. 2019 Jan;49(1):38-41 Front Immunol. 2016; 7: 19. Immun Ageing. 2020; 17: 16. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24): 8913–8918. Cells. 2021 Jun; 10(6): 1332 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: …
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BioMedical PortraitVI.c.13. Senescense and the aging of cells within systems apprehends the event ontologies of the stress phenomena-immune surveillance axis.DJGPhD.29.11.23. Authentic Biochemistry.
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References Annual Review of Pathological Mechanisms of Disease 2010. 5:99-118. Immun Ageing. 2020; 17: 16 Williams, Hank.1949. ISLICC. https://youtu.be/4WXYjm74WFI?si=mhYowh4ClIOKmgVX --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel…
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BioMedical Portrait VI. c.12. Obesity and viral infection-associated NK malfunction may lead to NASH and subsequent HCC. DJGPhD.28.11.23. Authentic Biochemistry
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References Ann. Review of Pathological Mechanisms of Disease2010.5:99-118. Nature 2013 Jul 4;499(7456):97-101. Front Immunol. 2018; 9: 476 Cells. 2021 Jun; 10(6): 1332 Nat Rev Gastroenterol Hepatol (2023). https://doi.org/10.1038/s41575-023-00846-4 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSuppor…
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BioMedical Portrait VI. c.11 NK cell involvement in HepatoCellular Carcinoma. DJGPhD. 26.11.23. Authentic Biochemistry
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References Front Immunol. 2018; 9: 476 Nature Reviews Gastroenterology & Hepatology 2023. 20: 662–678 (2023) Cells. 2021 Jun; 10(6): 1332. Traffic, (Traditional. arr. S Winwood )1970. "John Barleycorn Must Die" https://youtu.be/icyPFsIcAV0?si=XSVxsiojZBrwGPx6 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/me…
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References Dr Guerra's Metaphysics notes Schubert, F. 1828. Quintet in C. Major D.956 https://youtu.be/Dc3iX7x73JY?si=j4jlU4ra_488pAuE --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait VI.c.10.Alterations in the cytotoxic immune response can be dissociated from inflammation via intermediary metabolic mutation.DJGPhD.22.11.23. Authentic Biochemistry Pootdcast.
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References Front Immunol. 2023; 14: 1151166. Dr Guerra: Biochemistry lecture archives Telemann, G.P. 1725.Viola Concerto in G major https://youtu.be/yMpzPMkrALM?si=lpyDYITx63jTc6-K --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-…
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BioMedical PortraitVI.c.9 HLH mutations obtain complex NKvs.CD8+ T cell alterations in cytototoxicity and proliferation.DJGPhD.21.11.23 Authentic Biochemistry.
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References Immunobiology. 2019 Jan; 224(1): 94–101 Front. Immunol., 14 June 2023 Cell. 2003 Nov 14;115(4):461-73 VonBingen.H. Born 1098AD https://youtu.be/yyAQc0kPZpU?si=y26mnCOmFpRis63_ --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-dan…
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BioMedical Portrait VI.c.8.The cytotoxicity of the NK cell Is a function of its bioenergetics. Glycolysis/OXPHOS vs. FAO/OXPHOS during activation/proliferation
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References Front Immunol. 2023; 14: 1151166. Inflammation Research :official journal of the European Histamine Research Society 2018.1420-908X, Vol. 67, Issue 10. J Cell Sci. 2011 Dec 15; 124(24): 4147–4159. Hunter, R. and J. Garcia 1970. "Sugaree" https://music.youtube.com/watch?v=sxF9UJ-Rm0E&si=S4F0LvlFvUsTE1OO --- Send in a voice message: https:…
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BioMedical PortraitVI.C.7 IEI/IEM pathobiochemistry involves bioenergetics, transcriptional , translational, and post-translational modification sequalae.DJGPhD.19.11.23 Authentic Biochemistry.
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References Front Immunol. 2022; 13: 950536. Inflamm Res. 2018 Oct;67(10):813-828 Mol Biol Rep. 2023; 50(8): 6963–6974. Front Immunol. 2023; 14: 1151166 Dr Guerra: Graduate biochemistry lecture archive Schubert.F. 1827.December.Impromptu #3 in G flat major performed by Khatia Buniatishvili https://youtu.be/LUp2u9wI1fY?si=hhiUmiyXyQ78Qtaw and "Questi…
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BioMedical Portrait VI c.6.Hemophagocytic lymphohistiocytosis ACAD9/Rab27A/+/- FBase1 mutations linked to NK and CTL immunodeficiences.DJGPhD. 16/11/23. Authentic Biochemistry.
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References Front Immunol. 2023; 14: 1151166. Int J Mol Sci. 2019 Jan; 20(2): 443. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMed Portrait VIc.5. NK cell Inborn Error Of Immunity links to failed fatty acyl CoA dehydrogenase-obtained immunodeficiency.DJGPhD. 15.11.23. Authentic Biochemistry
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References Front Immunol. 2023; 14: 1151166 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMedical Portrait VI.c4. Tumor and DC antigen VAX directed melanoma therapy reveals CD8+CTL and NK cell surface population dynamics.DJGPhG.14.11.23. Authentic Biochemistry.
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References Cancers 2020, 12(4),952 JBC. 2018. 293: 2422-2437. J Immunother Cancer. 2021 Nov;9(11):e003675 Front Oncol. 2023 May 18:13:1145667 Front. Immunol.2019. Sec. Cancer Immunity and ImmunotherapyVolume 10 Int. J. Mol. Sci. 2019, 20(3), 646 Front Immunol. 2019; 10: 14 Vivaldi, A. 1716. RV589 Gloria https://youtu.be/2eWjQOdYzMQ?si=dpZaNZilqPXi6…
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BioMedical PortraitVIc.3. NK cell phenotypic variation is tighly regulated to facillitate unique immune sequalae including tumor ablation, pathogen elimination and autoimmunity.13.11.23.DJGPhD
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References Immunity. 2018 Oct 16;49(4):695-708 Front Immunol. 2019; 10: 14 Front. Immunol., 24 July 2017 Vol 8. Sec. T Cell Biology --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical ortrait VI. Development of a dendritic cell antigen presenting melanoma kinase derived vax targeting NK cells to ablate malignancy.DJGPhD.11NOV23
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References Front Immunol. 2019; 10: 14 Cancer Immunol Immunother. 2016 Apr;65(4):441-52 Anal Cell Pathol (Amst).2018; 2018: 787.1814. Molecular Cancer 2020. volume 19, Article number: 39 Cohan, G. 1917. "Over There" https://youtu.be/BYV044H5muI?si=LdANMG6dtXeC14tj --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guer…
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BioMedical Potrait VI. Natural Killer Cells: opening remarks. DJGPhD.9NOV23. Authentic Biochemistry
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References Anal Cell Pathol (Amst).2018; 2018: 787.1814 Zeno (the Eleatic) 5thCentury B.C. Magna Graecia, Italian Penn. Student of Parmenides Guerra-basic immunology lectures Schubert,F. 1826.String Quartet No. 15 in G major, D. 887. https://youtu.be/xW8PI2Xa8eA?si=smnLmSKamUP34qon --- Send in a voice message: https://podcasters.spotify.com/pod/sho…
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BioMedical Portrait V. Coda c.13 Small molecule pyrazolo-oxazepine derivitive mediated PFK-1 activation depletes NADPH dependent neutrophil oxidative burst. DJGPhD.07NOV23. Authentic Biochemistry
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References Cell 2021. 184, 1–15 J Zhejiang Univ Sci B. 2022 Jul 15; 23(7): 607–612. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMedical Portrait V.c.12. Is there a compositional-sequential event ontology linking "moonlighting"c-Fos with NOX2 PX domain PIP3 binding?DJGPhD. 6NOV23
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References Nature Communications 2019. volume 10, Article number: 1528 Adv Exp Med Biol. 2019:1111:1-17. doi10.1007/5584_2018_185. Nature Immunology volume 20, pages559–570 (2019) Biochem J. 2001 Dec 15; 360(Pt 3): 513–530. PNAS 1993. 90: 10952-10956 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupp…
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BioMedical Portrait V.c.11 The Phosphoglycerolipid metabolome that orchestrates membrane topology and surface chemistry that supports necessary protein association for neutrophil immunoresponses.
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ReferencesBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids2014.Volume 1841, Issue 9, Pages 1241-1246Guerra-graduate lipid lectures--- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait V.c.10. Phosphphatidyl inositols and phagosmal genesis in activated neutrophils upon pathogen infection.
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References J Adv Res. 2018 May; 11: 33–41. Immunol Rev. 2023. Volume314, Issue1 .Special Issue: Neutrophils and Friends.March 2023. Pages 158-180. Biochim Biophys Acta Biomembr.. 2023 Oct;1865(7):184180 Front Cell Dev Biol. 2022; 10: 945749. Tchaikovsky, PI., 1878.Violin Concerto in D major, Opus 35 (TH 59 ; ČW 54). https://youtu.be/2ckqOukGKK8?si=…
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BioMedical PortraitV.c9. Both glycolytic and OPP regulation combine complex allosteric and amphibolic sequalae that may converge on an immune- hyperinflammatory state. DJGPhD.2NOV23.
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References Guerra 2023-graduate biochemistry lecture canon and marginalia Mol Oral Microbiol. 2019 Apr; 34(2): 27–38. Front Cell Dev Biol. 2022; 10: 945749. Mozart, WA. 1784. Piano Concerto No. 17 in G major, KV. 453 https://youtu.be/iYNbMclI5Ls?si=_P9oK14c_wb98VXG --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-gue…
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BioMedical Portrait V.c8. NOX2 subunitorganization, oxygen availability and phase I discussion of glycolytic allosteric control.DJGPhD.01Nov23
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References FASEB 2017. Volume 31, Issue2 Pages 663-673 Guerra,DJ. Graduate Biochemistry Lectures Albioni , Thomaseo. 1708. Sonate da chiesa ("op. 4") (for violin and basso continuo), https://youtu.be/IMmjjcfG2c4?si=C4VG-rPWL_Fv7-Xe --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: h…
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BioMedical Portrait V C.5 Periodontitis-linked CVD. DJGPhD. 30.10.31
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References Eur J Microbiol Immunol (Bp). 2011 Mar;1(1): 41–58 J Periodontal Res. 2018 Jun; 53(3):403–413. DJGPhD lecture notes --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait V. c7. NETs and the combined activities of elastase,NOX2,MPO and IP3 PTEN phosphatase potentiate inflammation-linked pathologies of lung and pancreas. DJGPhD.31.10.23 and
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References J Zhejiang Univ Sci B. 2022 Jul 15; 23(7): 607–612 Biomaterials. 2020 Apr; 238: 119836. Int J Nanomedicine. 2023;18:5265-5287 Child Ballad 100. 1775. Pentangle. 1972.Willie O' Winsbury https://youtu.be/nwqP_yoszCE?si=C0NH51euOOTlPYn9 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport th…
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BioMedical Portrait V C.6 P. gingivalis Two Component System assembly and activation mediate infection court involvement in subsequent host vector pathology.DJGPhD. 30.10.23b.
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References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2):S135–S139. J Oral Microbiol. 2017; 9(1): 1400858 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMedical Portrait Vc4 Two component signal system pathogenic bacterial responses to host immunity and the gigipain cysteine protease opposing serum secretory IgA mediated phagocyte activation.DJGPhD
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References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2): S135–S139. J Oral Microbiol. 2017; 9(1): 1400858. J Dent Res. 2020 Jun;99(6):644-649. Mozart WA 1782. D major, K. 385. Symphony 35 (Haffner) --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/…
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BioMedical Portrait V.c3. The categorical analysis of Neutrophil involvement in multiple pathophysiologies requires cellular signaling to derivatize pleiotropic disease ontologies. DJGPhD.26.10.23
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References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Gut Microbes. 2022; 14(1): 2073785. Adv Exp Med Biol. 2020:1263:13-23 Bredon, Anne. 1950. Led Zepplin. 1969. https://youtu.be/dZitPJMh60A?si=MnEpM-iemNFWEKE7 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https:…
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BioMedical Portrait V. The neutrohil oxidative burst and the roles of Phox generating superoxide and peptide arginine deiminase in phagocyte defense against pathogens and contrarion disease promotion.
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ReferencesBlood (2004) 103 (11): 3993–3994Anticancer Agents Med Chem. 2023;23(3):256-265 Med Hypotheses. 2021 Jan:146:110466. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait V. Introductory alethic unfolding of neutrophil glycolysis associated hyperinflammatory restraint.
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References Cell. 2021 Aug 19;184(17):4480-4494.e15 Sci Rep. 2019 Mar 5;9(1):3433 Med Hypotheses. 2021 Jan:146:110466. Hayward, J. 1967. Moody Blues. "Tuesday Afternoon" https://youtu.be/jmMPBQ4kYKk?si=X0UyZJFq2AAnKSvJ --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcast…
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Continuing dialectical event ontology of epistemological requirements for validation of biochemical research. DJGPhD.23.10.23. Authentic Biochemistry Podcast
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Send an email to authenticbiochemistry@gmail.com with comments. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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All reciprocity in not disinterested so phenomena must be in equilibrium. But phenomena at equilibrium are invisible so reciprocity must be uncertain. DJGPhD.22.10.23. Authentic Biochemistry
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Vide supra. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMedical Portrait IV. Postcript DJGPhD. 21 October 2023. Authentic Biochemistry Podcast
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References Cureus. 2022. 14(9): e29696.doi:10.7759/cureus.29696 NMR Biomed. 2021 Feb;34(2):e4448. NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Nutrients. 2023 May; 15(9): 2029. Mozart, WA. 1791 K 626 Requiem in d minor. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://po…
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BioMedical Portrait IV. 13b. Magnetic Resonance Imaging as a non-invasive tool in Neurodegenerative Diseases. DJGPhD.19.10.23 Authentic Biochemistry.
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References Mol Cell Neurosci. 2012 Jan; 49(1): 44–53 NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5092–5094. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast
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References Brain. 2023 Sep 13:awad309. doi: 10.1093/brain/awad309 J Alzheimers Dis. 2016 Feb 26;52(1):43-50. Haydn, FJ. 1796. MISSA IN TEMPORE BELLI https://youtu.be/8_5tgmAwN-E?si=AYzyMMk47b2IUt0Y Send an email to Dr Guerra! authenticbiochemistry@gmail.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/mess…
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BioMedica; Portrait IV Coda II.c12. Biochemical Concatenations-the spatiotemporal sequences of molecular-cellular events of FTD's from proteinopathies to signalling and antigen recognition. DJGPhD.
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References Brain. 2023 Sep 13:awad309 McBroom, Amanda. 1970 "the Rose" httBps://youtu.be/cO59ITNCxzk?si=v-qx_2_mPq3zbCYH --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait IV c11. FTLD-tau is correlated with microglial and astrocytic inflammation and subsequent neural degeneration. DJGPhD. 16.10.23 Authentic Biochemistry.
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References Front. Immunol., 19 October 2022 Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast
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References Schubert, F. 1820. Rosamunde Overture. https://youtu.be/3Pc_LUItWQI?si=ZB3bsrmz3ReiJQdi Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23
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Mol Cell Biol. 2012 Jan;32(1):126-38 Mutat Res. 2013 Jul-Sep;753(1):24-40 Molecular Neurobiology 2022. volume 59, pages 4223–4241 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23.
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References Molecular Neurobiology 2022. volume 59, pages 4223–4241 Hum Genet. 1994 Jan;93(1):67-73 Mol Cell Biol. 2012 Jan;32(1):126-38 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry
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References The EMBO Journal (2022)41:e109108 Acta Neuropathol. 2007 Sep;114(3):221-9 Acta Neuropathol.2013 Jul; 126(1): 51–57 Brain 2008. Volume 131, Issue 6, Pages 1416–1432 Lovin Spoonful 1968. "She's a Lady" https://youtu.be/xyFdzevDOHg?si=bLl8FZzfE2SffvO4 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/me…
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BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD
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References Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74LR2JY The EMBO Journal (2022)41:e109108 PLoS ONE 2013. 8(6): e65646. doi:10.1371/journal.pone.0065646 Molecular Neurodegeneration 2022. volume 17,Article number: 73 --- Send in a voice message: https:/…
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BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation
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References Mozart, WA. 1791. Clarinet Concerto in A major, K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5 Small GTPases. 2014; 5: e28579 Acta Neuropathol. 2023; 145(6): 749–772 J Immunol. 2000 May 15;164(10):4991-5 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://p…
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BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.
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References Mol Biol Cell. 2001 Sep; 12(9): 2711–2720. Small GTPases. 2014; 5: e28579. Cells. 2021 Jul 20;10(7):1831. J Investig Med. 2023 Feb;71(2):113-123 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.
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References Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC Acta Neuropathol. 2023 Jun;145(6):749-772 Signal Transduction and Targeted Therapy 2022. volume 7, Article number: 175 Cardiovascular Research 2007. 74: 526 – 536 J Investig Med. 2023 Feb;71(2):113-123 --- Send in a voice message: https://podcasters.spotif…
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BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.
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References Neurol Genet. 2018 Jan 18;4(1):e211. J Immunol (2003) 171 (2): 594–599. Acta Neuropathol. 2023; 145(6): 749–772. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.
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References Neurology. 2020 Jul 7; 95(1): e46–e58 Acta Neuropathol. 2023; 145(6): 749–772. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD
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References Curr Opin Pharmacol. 2021 Apr; 57: 107–116 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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BioMedical PortraitIII. c13b.Immune cell metabolic dialectical usurpation of architechtonic control over inflammation and cell fate obtained from senescence and obesity.-linked dyslipidaemia.DJGPhD.
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References Pisendel Johann G. 1735. Violin Concerto in D major Jun P I.7 https://youtu.be/dvwhXXvFiNg?si=BUb-f5rBncgADinx Curr Opin Pharmacol. 2021 Apr; 57: 107–116 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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BioiMedical Portrait III. NLRP3 Inflammasome and senescence-associated heterochromatic foci in macrophages, Kuppfer Cells and Liver sinusoidal endothelial cells contibute to liver/adipose disease
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References Telemann Georg P. 1765. Overture D Major, TWV 55:D18 | Tafelmusik https://youtu.be/8r-IFLtN9x4?si=T2hp65oGT--dTivY Leukemia 2020 volume 34, pages 75–86 Nat Cell Biol. 2019 Mar; 21(3): 397–407 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com…
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BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD.
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References Haydn, Michael. 1760. Salve Regina in G MH32. https://youtu.be/u_Xjo5KJ3mg?si=kmKaaBJMvUgs_blX Leukemia 2020. volume 34, pages 75–86 CELL 2006. Volume 126, Issue 3, Pages 503-514 Nat Cell Biol. 2019 Mar; 21(3): 397–407. Curr Opin Pharmacol. 2021 Apr; 57: 107–116. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-dan…
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BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD.
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References Saint-Saens. C. 1886. Symphony 3 (avec orgue) OP.78 J Clin Invest. 2011 Dec 1; 121(12):4903–4915 Cell Metab. 2022 Dec 6; 34(12): 2036–2046.e8. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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