Got Guts: Aryl hydrocarbon receptor (AhR) function is required for optimal interleukin-22 signaling in colonic epithelial stem cells

27:39
 
シェア
 

Manage episode 347666736 series 3332773
著作 ajpgi の情報はPlayer FM及びコミュニティによって発見されました。著作権は出版社によって所持されます。そして、番組のオーディオは、その出版社のサーバから直接にストリーミングされます。Player FMで購読ボタンをタップし、更新できて、または他のポッドキャストアプリにフィードのURLを貼り付けます。

In this podcast, coauthors Dr. Huajun Han, and Prof. Robert S. Chapkin of Texas A&M University, discuss their recently published research "Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3" with Editor-in-Chief Prof. Mark Frey. Data from their preclinical orthogonal models indicate that AhR signaling modulates the response of colonic epithelial cells to IL22, resulting in the suppression of carcinogen-associated colon tumorigenesis. These findings provide rationale for targeting AhR as a means of ameliorating IBD and reducing colon cancer risk. Take a listen today!

Be sure to follow us on Twitter

Listen to other American Physiological Podcasts

11 つのエピソード