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The Science of Self-Care

The Science of Self-Care

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It feels like everything is self-care these days, so what actually works? Each week, comedians Steven Polletta and Sophie Yalkezian and neuroscientist Shannon Odell act as guinea pigs to a different self-care practice. They explore what it does and the science behind it with laughs along the way. You'll leave each episode with an expert opinion, new friends and a bounce in your step, guaranteed. Follow us on social media! Instagram: @thescienceofselfcare Twitter: @SOSCpodcast Have a question ...
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The Health Edge: translating the science of self-care

Mark Pettus MD and John Bagnulo PhD, MPH

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“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”. Will RogersWe believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from th ...
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In this Health Edge recording, Mark describes a model of integrative health-lifestyle medicine that is distinctly different from current allopathic disease-based models. He examines the metabolic perfect storm of insulin resistance and inflammation as passports to accelerated aging, chronic complex disease risk and poor quality of life or healthspa…
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In this episode of the Health Edge I review a recent meta-analysis examining the magnitude of cardiovascular benefit from taking statins for elevated LDL in both primary and secondary prevention. JAMA Intern Med. 2022;182(5):474-481. doi:10.1001/jamainternmed.2022.0134 Published online March 14, 2022. https://pubmed.ncbi.nlm.nih.gov/35285...…
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Do you ever feel like everything you've been told about healthy eating seems to be teetering on the edge of being overturned? Welcome to a mind-bending exploration where we question the status quo, particularly the demonization of full fat dairy and saturated fats. I'm diving deep into a groundbreaking study suggesting that pentadecanoic acid, a sa…
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In a world where health advice is abundant, it can be challenging to sift through conflicting data and headlines. One such contentious issue is the connection between red meat and type 2 diabetes. On this episode of The Health Edge, we take a critical look at this connection and aim to provide a balanced perspective on this often polarizing topic. …
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Ready to have your understanding of BMI flipped on its head? We're diving into an intriguing study that suggests a BMI lower than 25 might be linked with decreased mortality. That's right, what you've been told about the ideal BMI could be all wrong. We also tackle the waist to hip ratio, showing you how to measure it and why it might be a better h…
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Are you ready to unlock the mysteries of protein and its pivotal role in our dietary intake? Strap in as we guide you through the complex world of essential amino acids, and the significant part they play in our bodies. We discuss the importance of achieving a balance in your protein consumption, focusing on the dietary reference intakes, and the p…
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In this podcast Mark reviews the current paradigm linking environmental inputs-lifestyle with epigenetics and the human microbiome. He translates these connections ibto effective lifestyle medicine interventions. The PowerPoint below goes with the audio recording. You Tube recording can be found below. PowerPoint slides can be downloaded at www.the…
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In this episode of the Health Edge Mark and John discuss areas of research they are closely following. John shares some interesting fatty acid research and introduces heptadecanoic acid as an emerging 17-carbon fat, important to healthy brain aging. Mark reviews some aging and longevity research he is following. Topics include epigenetic aging, bio…
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In this episode of The Health Edge Mark and John review some papers that challenge the well accepted clinical meme that lowering LDL should be the focal point of reducing CV risk and all-cause mortality risk. Papers referenced: https://www.nature.com/articles/s4159... https://bmjopen.bmj.com/content/6/6/e... https://www.ncbi.nlm.nih.gov/pmc/arti...…
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In this episode of The Health Edge Mark and John review a recent paper drawing connections between excessive sodium restriction and insulin resistance. This adds to a growing body of research suggesting the restriction of sodium below 3-4 gms/day may in fact add to cardiometabolic risk. Current guidelines of 2300 mg/day or less fall well below thes…
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This is a replay of a prior podcast examining the relationship between sodium and hypertension. A growing body of research suggests there is a point below which e.g. 3,000 mg/day where risk is increased. This recording is a prelude to our upcoming podcast on sodium restriction and insulin resistance.…
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In this Health Edge podcast recording, Mark and John review a recent paper that drew a strong relationship between erythritol levels in the blood with major adverse cardiovascular (MACE) events. Mark and John anayize the study and offer perspective. https://www.nature.com/articles/s41591-023-02223-9 Another recent review of risks and benefits of er…
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That's a wrap on Season 3! We're diving into the science behind Tetrahydrocannabinol, aka THC, aka cannabis, aka weed, aka all the other things we've ever called weed in an effort to be "subtle" and "cool". Steven and Sophie reminisce on anti-drug campaigns and insist on reading through Rachel Leigh Cook's filmography. Shannon explains how the drug…
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This week, the self-care gang talks through the impact that moving homes can have on your brain, and shares advice on how to take care of yourself before, during, or after a move. Shannon and Sophie detail their highs and lows from recent experiences, and everyone agrees Steven could easily be a real estate agent.…
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In this Health Edge recording Mark and John review recent data on the prevalence of CKD in the US. They review common drivers of CKD and offer many lifestyle medicine recommendations for prevention and management.Mark Pettus MD and John Bagnulo PhD, MPH による
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In this episode of the Health Edge, mark and John review two important studies. The first is a systematic review/meta analysis that clearly links loss of lean body mass (sarcopenia) with all-cause mortality and cardiovascular disease risk. The second paper reviews the underlying mechanisms that link lower muscle mass with greater risk of cognitive …
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Does tracking your steps motivate you to walk more each day? Can monitoring your heart rate help you exercise more efficiently? Today, we're digging into all the science behind wearable technologies. That means everything from Fitbits to Smart Shoes to the everyday iPhone. Plus, the crew offers their best tips for when you want to get your body mov…
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Few age-related diseases are more devastating than Alzheimer's. A recent study from Columbia University suggests in individuals 65+ years of age, 10% have a dementia diagnosis and almost 25% have a diagnosis of MCI or mild cognitive decline. For the 90+ age demographic, over 30% have a dementia diagnosis. The costs to the individuals and those who …
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Cardiovascular disease continues to be the #1 cause of mortality in the US and around the world. In this episode of The Health Edge, Mark and John review a paper that begins to address why it is that as we age, our risk for cardiovascular disease (CVD) and all other "age-related diseases" goes up dramatically. In this 2021 paper from the Journal of…
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In this recording of The Health Edge, Mark and John discuss the importance of dietary intake and sources of omega 6 and omega 3 fats. An abundance of epidemiological and clinical trials suggest high ratios of O-6/O-3 drive increased inflammation, oxidative stress and are associated with increased cardiovascular and all-cause mortality. Mark and Joh…
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In this episode of The Health Edge Mark and John review some recent studies that continue to challenge the long held belief that saturated fatty acid intake (SFAs) is directly linked to diabetes and cardiometabolic risk. https://www.thelancet.com/article/S0140-6736(17)32252-3/fulltext https://pubmed.ncbi.nlm.nih.gov/36056919/…
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In this recording of The Health Edge, Mark and John interview Mark Campbell PhD. We discuss the science linking time in Nature with global health outcomes. About Mark Campbell: Dr. Mark A. Campbell uses his background in wellness, sports medicine, exercise science, and performance psychology to impact change across all areas of life. His diverse ba…
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In this episode of The Health Edge Mark and John review a recent study published by the Journal of the American College of Cardiology, Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Mark and John reflect on how we got here and why this is so important to recognize and respond to. Lifestyle drivers and interventions a…
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Is it possible that consuming too much fruit could be detrimental to your health? Are all fruits the same? In this recording of The Health Edge Mark and John will explore the relationship between dietary fructose intake (from sugar and high fructose corn syrup and fruits), endogenous metabolic conversion of glucose to fructose (high glycemic foods)…
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In this episode of The Health Edge Mark and John review two papers that suggest higher levels of vitamin D via supplementation may slow our biologic clocks as measured by epigenetic methylation patterns. The implications are fascinating! YouTube link: https://youtu.be/O3UD62Pk9fE Papers reviewed: Vitamin D supplementation is associated with slower …
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In this episode of The Health Edge Mark and John review a recently published paper affirming proof of concept: healthy lifestyle may in fact reverse biologic aging or slow "biologic clocks" via epigenetic methylation patterns. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial https://www…
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In this episode of The Health Edge, Mark shares a recording from January 21, 2022 reviewing the current science of aging and longevity. This was the first of a series of 6 webinars sponsored by OLLI Berkshires. https://berkshireolli.org/ScienceOfAgingWinter22 The pdf handout from this presentation can be downloaded at www.thehealthedgepodcast.com…
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In this episode of The Health Edge Mark and John review a paper demonstrating significant reductions in NAFLD with both 5:2 fasting mimicking or LCHF over just 12 weeks. Article can be found at: https://reader.elsevier.com/reader/sd/pii/S258955592100032X?token=5364332DCA18EABB9179131EF7F061F8AE705EE83CE947284A96CC9749AC9AF4E4C9FDA2D11BF95A0800388E3…
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In this Health Edge podcast, John and Mark review a recent paper published in the New England Journal of Medicine that links higher intake of high-glycemic foods and beverages with higher all-cause mortality and cardiovascular disease. https://www.nejm.org/doi/full/10.1056/NEJMoa2007123Mark による
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Drew Pearlman Interview: Dr. Mark Pettus is a triple-board certified Internist, Nephrologist, and Integrative Medicine physician practicing for over 25 years. He is also the author of two books, The Savvy Patient: The Ultimate Advocate for Quality Health Care and It’s All in Your Head: Change Your Mind, Change Your Health. He hosts The Health Edge …
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In this videocast of The Health Edge Mark and John review some research linking higher intake of microbiota associated carbs (MAC) with biome diversity and health outcomes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143995/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896489/Mark による
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In this Health Edge podcast, John and Mark review a paper that reviews the many effects of UVB light on the skin and systemic neuroendocrine and immune systems. They discuss the importance of photobiomodulation and the health implications. For mind, mood, pain, and inflammation, our sophisticated skin and retinal chromophores are quantum portals to…
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In this Health Edge recording Mark and John review a paper by Pulitzer Prize winning journalist Jared Diamond PhD. In this paper, Dr. Diamond suggested, "The adoption of agriculture, supposedly our most decisive step toward a better life, was in many ways a catastrophe from which we have never recovered."…
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