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NEJM This Week

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NEJM This Week

The New England Journal of Medicine

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The New England Journal of Medicine (NEJM) Weekly Audio Summary. Everything newly published this week in NEJM (nejm.org). Listen to a concise summary of articles and their findings published in the current issue.
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NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations w ...
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Curbside Consults take a deep dive into key topics with expert clinicians and educators. As we explore the details of pathophysiology and critique the evidence behind clinical practice, these conversations are intended to give you better understanding of the topic and greater confidence when treating your patients.
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Featuring articles on tirofiban for stroke, a five-year follow-up after transcatheter repair of secondary mitral regurgitation, diagnostic imaging for pediatric forearm fractures, and AKT pathway inhibition in HR-positive breast cancer; a review article on adipose tissue and insulin sensitivity; a Clinical Problem-Solving describing a wrong turn; a…
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Large language models (LLMs) like ChatGPT have proven highly capable of a broad array of natural language tasks including summarizing text, generating prose, and answering questions. This episode’s two guests, Dr. Alan Karthikesalingam and Vivek Natarajan of Google, describe their team’s recent efforts to adapt and evaluate LLMs for clinical applic…
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Featuring articles on hydrocortisone in severe community-acquired pneumonia, a meningococcal vaccine in Mali and Gambia, platelet transfusion before CVC placement in patients with thrombocytopenia, and upadacitinib therapy for Crohn’s disease; a review article on using AI to interpret medical images; a case report of a boy with depression and hypot…
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Featuring articles on transcatheter repair for tricuspid regurgitation, rifapentine in household contacts of persons with leprosy, peresolimab for rheumatoid arthritis, and emodepside for T. trichiura and hookworm infections; a review article on tricuspid regurgitation; a case report of a man with paresthesia of the arms and legs; and Perspective a…
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Featuring articles on anti-CD20 antibodies and venetoclax in chronic lymphocytic leukemia, epicutaneous immunotherapy in toddlers with peanut allergy, cabozantinib in advanced renal-cell carcinoma, and racial inequality in the receipt of medications for opioid use disorder; a review article on HPV vaccination; a case report of a man with redness of…
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Featuring articles on interrupting therapy to attempt pregnancy after breast cancer, trifluridine–tipiracil and bevacizumab in colorectal cancer, imaging- or angiography-guided PCI for complex lesions, and idiopathic CD4 lymphocytopenia; a review article on neonatal seizures; a Clinical Problem-Solving describing a diagnostic sequence; and Perspect…
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Featuring articles on a 15-year follow-up of prostate cancer therapies, on deciphering developmental disorders, blinatumomab in infant acute lymphoblastic leukemia, and a BCG vaccination against Covid-19; a review article on advances in AI for infectious-disease surveillance; a case report of a woman with abdominal pain and jerking movements; and P…
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Dr. Michael Abramoff is a renowned ophthalmologist and medical AI pioneer. In this episode, we explore his groundbreaking work that led to the first FDA-authorized device that does not require a physician, IDx-DR, which detects more than mild diabetic retinopathy from digital images of the eye. Dr. Abramoff also reflects on the challenges of commer…
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Featuring articles on an RSV vaccine in pregnancy, an RSV vaccine in older adults, sotatercept for pulmonary arterial hypertension, the burden of typhoid and paratyphoid fever in India, cerebral oximetry in extremely preterm infants, and on immune checkpoint inhibitors; a case report of a woman with muscle weakness and myalgia; and Perspective arti…
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Featuring articles on bempedoic acid in statin-intolerant patients, tranexamic acid to prevent hemorrhage after cesarean delivery, an oral melanocortin receptor agonist in porphyria, the influence of blood-donor sex on recipient mortality, and on air pollution, mortality, race, and social class; a review article on screening for prostate cancer; a …
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In this episode of Curbside Consults, we examine the 2022 scientific statement from the American Heart Association on the management of acute coronary syndrome in the older adult population. We are joined by Dr. Abdulla Damluji, the lead author on the scientific statement. Dr. Damluji is an interventional cardiologist at Inova Heart and Vascular In…
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Featuring articles on thrombectomy for large ischemic strokes, CAR T cells for relapsed or refractory neuroblastoma, postexposure doxycycline to prevent bacterial STIs, and the genetic risk of low-grade glioma; a review article on primary Budd–Chiari syndrome; a Clinical Problem-Solving on an alternate explanation; and Perspective articles on ensur…
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Featuring articles on azithromycin to prevent sepsis or death during birth, transcatheter arterialization for limb ischemia, gene–environment interactions and the risk of gastric cancer, vedolizumab for the treatment of chronic pouchitis, a general AI chatbot for medicine, and on dark-alley ethics; a review article on artificial intelligence and ma…
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Dr. Peter Lee has shaped computer science from academia, government, and industry. He has chaired a major computer science department, built a new technology office at DARPA, and now serves as Corporate Vice President at Microsoft, where he leads Microsoft Research and its nine worldwide laboratories. In this episode, Peter reveals Microsoft’s inte…
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In this episode of Curbside Consults, Jaclyn Albin, MD and Milette Siler, RD share their passion for food as medicine and talk about their experiences at The Culinary Medicine Program at UT Southwestern Medical Center. Jaclyn believes food as medicine delivers a unique opportunity to integrate the clinical, educational, research, and public health …
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Featuring articles on augmenting or switching antidepressants in older adults, lebrikizumab for moderate-to-severe atopic dermatitis, the acute health effects of coffee consumption, Covid-19 staff testing and outcomes in nursing homes, and an mRNA influenza vaccine; a review article on right ventricular failure; a case report of a man with shortnes…
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Featuring articles on inaxaplin in persons with two APOL1 variants, expectant management or early ibuprofen for patent ductus arteriosus, closed-loop control in children with diabetes, BCMA-specific CAR T cells in refractory myeloma; a review article on translation defects in neurodegenerative diseases; a case report of a woman with refractory hemo…
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In this episode of Curbside Consults, we examine the Endocrine Society’s 2022 Clinical Practice Guideline on management of hyperglycemia in hospitalized adults in non-critical care settings. We are joined by Dr. Mary Korytkowski, Emeritus Professor of Medicine at the University of Pittsburgh and one of the guideline authors.…
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Dr. Lily Peng has driven major medical AI efforts along the long and arduous path from ideation to deployment. From publishing a landmark study in 2016 presenting an AI model to detect diabetic retinopathy in retinal fundus photographs to evaluating deep learning systems in India and Thailand, she has a unique and wide-ranging perspective on both m…
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In this episode of Curbside Consults, we examine the American College of Chest Physicians recent clinical practice guideline on Perioperative Management of Antithrombotic Therapy. We are joined by Dr. James Douketis, Chair in Thromboembolic Disease at McMaster University and the first author of the guideline.…
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In this episode of Curbside Consults, we examine the 2022 revision of the clinical practice guideline on the management of hyperbilirubinemia in the newborn infant by the American Academy of Pediatrics (AAP). We are joined by two authors of the revised guideline: Dr. Alex R. Kemper, the Division Chief of Primary Care Pediatrics at Nationwide Childr…
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Dr. Pranav Rajpurkar has been at the forefront of medical AI for his entire career. As a graduate student in computer science at Stanford, he created some of the first AI models for radiology and created a suite of datasets and benchmarks that have been widely used by researchers across the world. Now, as a faculty member at Harvard, his group has …
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In this episode of Curbside Consults, we discuss aerospace medicine with two physicians who are double boarded in internal and aerospace medicine and are also NASA astronauts. Dr. Auñón-Chancellor recently served as Flight Engineer on the International Space Station for Expeditions 56 and 57. She is an internist at Louisiana State University Health…
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